RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma.

Lu, Zhaoming; Shi, Xiaojing; Gong, Fanghua; Li, Shenglei; Wang, Yang; Ren, Yandan; Zhang, Mengyin; Yu, Bin; Li, Yan; Zhao, Wen; Zhang, Jianying; Hou, Guiqin

Lu, Zhaoming; Shi, Xiaojing; Gong, Fanghua; Li, Shenglei; Wang, Yang; Ren, Yandan; Zhang, Mengyin; Yu, Bin; Li, Yan; Zhao, Wen; Zhang, Jianying; Hou, Guiqin.

Afiliación

Lu Z; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Shi X; Collaborative Innovation Center of Cancer Chemoprevention, Zhengzhou 450001, China.
Gong F; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Li S; School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China.
Wang Y; The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Ren Y; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Zhang M; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Yu B; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Li Y; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Zhao W; Center of Advanced Analysis & Gene Sequencing, Zhengzhou University, Zhengzhou 450001, China.
Zhang J; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Hou G; Henan Academy of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052, China.

Acta Pharm Sin B ; 10(6): 1004-1019, 2020 Jun.

Article en En | MEDLINE | ID: mdl-32642408

Palabras clave

4EBP-1, E binding protein-1; AKT; AKT, protein kinase B (PKB); ESCC, esophageal squamous cell carcinoma; Esophageal squamous cell carcinoma; FDA, U.S. Food and Drug Administration; H&E staining, hematoxylin and eosin staining; IC50, half maximal inhibitory concentration; PI3K, phosphatidylinositol 3 kinase; RAD001; RICTOR; RICTOR, rapamycin-insensitive companion of mTOR; TNM, tumor-node-metastasis; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling; mTOR, mammalian target of rapamycin; mTORC1, mTOR complex 1; mTORC2, mTOR complex 2; p70S6K, p70 ribosomal S6 kinase-1; pp242; rapalogs, rapamycin and its analogs

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Acta Pharm Sin B Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google