Evolution of the mutation rate across primates.

Chintalapati, Manjusha; Moorjani, Priya

Chintalapati, Manjusha; Moorjani, Priya.

Afiliación

Chintalapati M; Department of Molecular and Cell Biology, University of California, Berkeley, CA, United States; Center for Computational Biology, University of California, Berkeley, CA, United States.
Moorjani P; Department of Molecular and Cell Biology, University of California, Berkeley, CA, United States; Center for Computational Biology, University of California, Berkeley, CA, United States. Electronic address: moorjani@berkeley.edu.

Curr Opin Genet Dev ; 62: 58-64, 2020 06.

Article en En | MEDLINE | ID: mdl-32634682

RESUMEN

Germline mutations are the source of all heritable variation. In the past few years, whole genome sequencing has allowed direct and comprehensive surveys of mutation patterns in humans and other species. These studies have documented substantial variation in both mutation rates and spectra across primates, the causes of which remain unclear. Here, we review what is currently known about mutation rates in primates, highlight the factors proposed to explain the variation across species, and discuss some implications of these findings on our understanding of the chronology of primate evolution and the process of mutagenesis.

Asunto(s)

Evolución Biológica; Genoma; Genómica/métodos; Tasa de Mutación; Mutación; Primates/genética; Animales; Primates/clasificación

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Primates / Genoma / Genómica / Evolución Biológica / Tasa de Mutación / Mutación Límite: Animals Idioma: En Revista: Curr Opin Genet Dev Asunto de la revista: GENETICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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