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The effect of the entry and re-entry size in the aortic dissection: a two-way fluid-structure interaction simulation.
Keramati, Hamed; Birgersson, Erik; Ho, Jackie P; Kim, Sangho; Chua, Kian Jon; Leo, Hwa Liang.
Afiliación
  • Keramati H; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore.
  • Birgersson E; Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.
  • Ho JP; Department of Mechanical Engineering, National University of Singapore, Singapore, Singapore.
  • Kim S; Department of Cardiac, Thoracic and Vascular Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Chua KJ; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Leo HL; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore.
Biomech Model Mechanobiol ; 19(6): 2643-2656, 2020 Dec.
Article en En | MEDLINE | ID: mdl-32621161
Aortic dissection (AD) is one of the most catastrophic cardiovascular diseases. AD occurs when a layer inside the aorta is disrupted and gives rise to the formation of a true lumen and a false lumen. These lumens can be connected through tears in the intimal flap which are known as entries. Despite being known for about two centuries, the effects of many factors on the morbidity and mortality of this disease are still unknown. As the blood interaction with the aorta is crucial in the severity and the progression of the aortic dissection, a biomechanical approach is chosen to investigate the influence of different morphologies on the severity of this disease. Using the finite element method (FEM) and the fluid-structure interaction (FSI) approach, we have evaluated the blood flow characteristics along the diseased aorta, in conjunction with the deformation of the aortic wall. In this study, an idealized geometry of a dissected descending aorta (type B) with two entries has been studied. The values for the diameter of the entry tear were chosen to be 5 mm and 10 mm. Therefore, a total of four conditions were investigated. According to our results, the retrograde flow through the proximal tear is dependent on the size of the distal re-entry and vice versa. Our results revealed that when both entry and re-entry tears are 10 mm in diameter, the flow passes through the true and false lumens with smaller resistance, resulting in a smaller flutter of the intimal flap, and therefore more stable intimal flap. Major oscillation frequencies of 2.5 Hz and 7.4 Hz were observed for the oscillation of the intimal flap, and amplitudes of the waves with higher frequencies were negligible.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Velocidad del Flujo Sanguíneo / Aneurisma de la Aorta Torácica / Hemodinámica / Disección Aórtica Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biomech Model Mechanobiol Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Velocidad del Flujo Sanguíneo / Aneurisma de la Aorta Torácica / Hemodinámica / Disección Aórtica Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biomech Model Mechanobiol Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Alemania