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Halogenases: structures and functions.
Ludewig, Hannes; Molyneux, Samuel; Ferrinho, Scarlet; Guo, Kai; Lynch, Rosemary; Gkotsi, Danai S; Goss, Rebecca Jm.
Afiliación
  • Ludewig H; School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.
  • Molyneux S; School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.
  • Ferrinho S; School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.
  • Guo K; School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.
  • Lynch R; School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.
  • Gkotsi DS; School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.
  • Goss RJ; School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK. Electronic address: rjmg@st-andrews.ac.uk.
Curr Opin Struct Biol ; 65: 51-60, 2020 12.
Article en En | MEDLINE | ID: mdl-32619660
Over 5000 halogenated natural products have been reported so far, many of these arising from the marine environment. The introduction of a halogen into a molecule can significantly impact its bioavailability and bioactivity. More recently enzymatic halogenation has been used to enable late stage functionalisation through site-selective halogenation and cross-coupling. Halogenases are becoming increasingly valued tools. This review outlines the various classes of halogenases that have been discovered, and examines these from both a structural and a mechanistic perspective, reflecting upon the many recent advances in halogenase discovery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cloruro Peroxidasa / Halogenación Idioma: En Revista: Curr Opin Struct Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cloruro Peroxidasa / Halogenación Idioma: En Revista: Curr Opin Struct Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido