Disruption of Osteoprotegerin has complex effects on medial destruction and adventitial fibrosis during mouse abdominal aortic aneurysm formation.

Bumdelger, Batmunkh; Otani, Mikage; Karasaki, Kohei; Sakai, Chiemi; Ishida, Mari; Kokubo, Hiroki; Yoshizumi, Masao

Bumdelger, Batmunkh; Otani, Mikage; Karasaki, Kohei; Sakai, Chiemi; Ishida, Mari; Kokubo, Hiroki; Yoshizumi, Masao.

Afiliación

Bumdelger B; Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Otani M; Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Karasaki K; Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Sakai C; Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Ishida M; Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Kokubo H; Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Yoshizumi M; Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

PLoS One ; 15(7): e0235553, 2020.

Article en En | MEDLINE | ID: mdl-32614927

Asunto(s)

Adventicia/patología; Aneurisma de la Aorta Abdominal/patología; Osteoprotegerina/genética; Adventicia/fisiología; Angiotensina II/farmacología; Animales; Aorta Abdominal/patología; Aorta Abdominal/fisiología; Apolipoproteínas E/deficiencia; Apolipoproteínas E/genética; Colesterol/sangre; Colágeno Tipo I/metabolismo; Modelos Animales de Enfermedad; Fibrosis; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Miofibroblastos/citología; Miofibroblastos/metabolismo; Osteoprotegerina/deficiencia; Ligando Inductor de Apoptosis Relacionado con TNF/metabolismo; Regulación hacia Arriba/efectos de los fármacos

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aneurisma de la Aorta Abdominal / Osteoprotegerina / Adventicia Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos

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