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Association of triple positivity with prognostic parameters and overall survival in a population-based study of 6,122 HER2-positive breast cancer patients: analysis of real-world clinical practice based on a research database.
Kolarova, I; Vanasek, J; Dolezel, M; Stuk, J; Hlavka, A; Dusek, L; Melichar, B; Büchler, T; Ryska, A; Prausova, J; Petrakova, K; Tesarova, P; Petera, J; Vosmik, M; Horackova, K; Jarkovsky, J.
Afiliación
  • Kolarova I; Department of Oncology and Radiotherapy, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
  • Vanasek J; Faculty of Health Studies, University of Pardubice, Pardubice, Czech Republic.
  • Dolezel M; Faculty of Health Studies, University of Pardubice, Pardubice, Czech Republic.
  • Stuk J; Department of Medical and Radiation Oncology, Pardubice Hospital, Pardubice, Czech Republic.
  • Hlavka A; Radiology Centre Multiscan, Ltd., Pardubice, Czech Republic.
  • Dusek L; Department of Oncology, Palacky University Medical School and Teaching Hospital, Olomouc, Czech Republic.
  • Melichar B; First Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Büchler T; Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
  • Ryska A; Radiology Centre Multiscan, Ltd., Pardubice, Czech Republic.
  • Prausova J; Department of Medical and Radiation Oncology, Pardubice Hospital, Pardubice, Czech Republic.
  • Petrakova K; Radiology Centre Multiscan, Ltd., Pardubice, Czech Republic.
  • Tesarova P; Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
  • Petera J; Department of Oncology and Radiotherapy, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
  • Vosmik M; Department of Oncology, Palacky University Medical School and Teaching Hospital, Olomouc, Czech Republic.
  • Horackova K; Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
  • Jarkovsky J; Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
Neoplasma ; 67(6): 1373-1383, 2020 Nov.
Article en En | MEDLINE | ID: mdl-32614235
Triple-positive breast cancer (TPBC), i.e. HER2-positive (HER2+) and hormone receptors-positive breast cancer, is a specific subgroup of breast cancers. TPBC biology is characterized by strong mutual interactions between signaling pathways stimulated by estrogens and HER2 amplification. The present study aims to carry out a population-based analysis of treatment outcomes in a cohort of hormone receptor (HR) positive and negative breast cancer patients who were treated with anti-HER2 therapy in the Czech Republic. The BREAST research database was used as the data source for this retrospective analysis. The database covers approximately 95% of breast cancer patients treated with targeted therapies in the Czech Republic. The analysis included 6,122 HER2-positive patients. The patients were divided into two groups, based on estrogen receptor (ER) or progesterone receptor (PR) positivity: hormone receptor negative (HR-) patients had both ER- and PR-negative tumors (n=2,518), unlike positive (HR+) patients (n=3,604). HR+ patients were more often diagnosed premenopausal at the time of diagnosis, presented more often at stage I or II and their tumors were less commonly poorly differentiated. The overall survival (OS) was significantly higher in subgroups of HR+ patients according to treatment setting. When evaluated by stages, significantly higher OS was observed in HR+ patients diagnosed at stages II, III, and IV and regardless of tumor grade.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Receptor ErbB-2 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans País/Región como asunto: Europa Idioma: En Revista: Neoplasma Año: 2020 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Eslovaquia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Receptor ErbB-2 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans País/Región como asunto: Europa Idioma: En Revista: Neoplasma Año: 2020 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Eslovaquia