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1,10-seco guaianolide-type sesquiterpenoids from Chrysanthemum indicum.
Xue, Gui-Min; Xue, Jin-Feng; Zhao, Chen-Guang; Zhao, Zhen-Zhu; Zhi, Yan-Le; Du, Kun; Li, Han-Wei; Sun, Yan-Jun; Feng, Wei-Sheng.
Afiliación
  • Xue GM; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
  • Xue JF; Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Zhengzhou 450046, China.
  • Zhao CG; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
  • Zhao ZZ; Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Zhengzhou 450046, China.
  • Zhi YL; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
  • Du K; Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Zhengzhou 450046, China.
  • Li HW; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
  • Sun YJ; Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Zhengzhou 450046, China.
  • Feng WS; College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.
J Asian Nat Prod Res ; 23(9): 877-883, 2021 Sep.
Article en En | MEDLINE | ID: mdl-32603195
ABSTACTA chemical investigation of the whole plant of traditional Chinese medicine, Chrysanthemum indicum L., led to the discovery of six guaianolide-type sesquiterpenoids 1-6 with a 1,10-splited skeleton. The structure of the new compound 1 was established by extensive analysis of UV, IR, MS, NMR and ECD data. Compounds 3-6 are mutually stereoisomers with four chiral centers and their absolute configurations were determined by comparison of ECD spectra. The anti-inflammatory effects of these isolates on lipopolysaccharide (LPS)-induced nitric oxide (NO) were investigated in RAW 264.7 cells. Results showed that most of the compounds displayed NO production inhibitory activities with IC50 values ranged from 3.54 to 8.17 µM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesquiterpenos / Chrysanthemum Límite: Animals Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesquiterpenos / Chrysanthemum Límite: Animals Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido