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Patterns of salivary microbiota injury and oral mucositis in recipients of allogeneic hematopoietic stem cell transplantation.
Shouval, Roni; Eshel, Adi; Dubovski, Bar; Kuperman, Amir A; Danylesko, Ivetta; Fein, Joshua A; Fried, Shalev; Geva, Mika; Kouniavski, Elizaveta; Neuman, Hadar; Armon-Omer, Ayelet; Shahien, Radi; Muller, Efrat; Noecker, Cecilia; Borenstein, Elhanan; Louzoun, Yoram; Nagler, Arnon; Koren, Omry.
Afiliación
  • Shouval R; Hematology and Bone Marrow Transplantation Division, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Eshel A; Dr Pinchas Bornstein Talpiot Medical Leadership Program, Chaim Sheba Medical Center, Tel Hashomer, Israel.
  • Dubovski B; Adult Bone Marrow Transplantation Service, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Kuperman AA; Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.
  • Danylesko I; Department of Mathematics, Bar Ilan University, Ramat Gan, Israel.
  • Fein JA; Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.
  • Fried S; Blood Coagulation Service and Pediatric Hematology Clinic, Galilee Medical Center, Nahariya, Israel.
  • Geva M; Hematology and Bone Marrow Transplantation Division, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Kouniavski E; Hematology and Bone Marrow Transplantation Division, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Neuman H; University of Connecticut Medical Center, Farmington, CT.
  • Armon-Omer A; Hematology and Bone Marrow Transplantation Division, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Shahien R; Hematology and Bone Marrow Transplantation Division, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Muller E; Hematology and Bone Marrow Transplantation Division, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Noecker C; Ziv Medical Center, Zefat, Israel.
  • Borenstein E; Ziv Medical Center, Zefat, Israel.
  • Louzoun Y; Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.
  • Nagler A; Ziv Medical Center, Zefat, Israel.
  • Koren O; The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel.
Blood Adv ; 4(13): 2912-2917, 2020 07 14.
Article en En | MEDLINE | ID: mdl-32598476
Oral mucositis (OM) is a common debilitating dose-limiting toxicity of cancer treatment, including hematopoietic stem cell transplantation (HSCT). We hypothesized that the oral microbiome is disturbed during allogeneic HSCT, partially accounting for the variability in OM severity. Using 16S ribosomal RNA gene sequence analysis, metabolomic profiling, and computational methods, we characterized the behavior of the salivary microbiome and metabolome of 184 patients pre- and post-HSCT. Transplantation was associated with a decrease in oral α diversity in all patients. In contrast to the gut microbiome, an association with overall survival was not detected. Among 135 patients given methotrexate for graft-versus-host disease prophylaxis pre-HSCT, Kingella and Atopobium abundance correlated with future development of severe OM. Posttransplant, Methylobacterium species were significantly enriched in patients with severe OM. Moreover, the oral microbiome and metabolome of severe OM patients underwent distinct changes post-HSCT, compared with patients with no or mild OM. Changes in specific metabolites were well explained by microbial composition, and the common metabolic pathway was the polyamines pathway, which is essential for epithelial homeostasis. Together, our findings suggest that salivary microbial composition and metabolites are associated with the development of OM, offering new insights on pathophysiology and potential avenues of intervention.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estomatitis / Trasplante de Células Madre Hematopoyéticas / Microbiota / Microbioma Gastrointestinal / Enfermedad Injerto contra Huésped Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Blood Adv Año: 2020 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estomatitis / Trasplante de Células Madre Hematopoyéticas / Microbiota / Microbioma Gastrointestinal / Enfermedad Injerto contra Huésped Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Blood Adv Año: 2020 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos