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Role of prothrombin 19911 A>G polymorphism, blood group and male gender in patients with venous thromboembolism: Results of a German cohort study.
Limperger, Verena; Kenet, Gili; Kiesau, Bettina; Köther, Max; Schmeiser, Malin; Langer, Florian; Juhl, David; Shneyder, Maria; Franke, Andre; Klostermeier, Ulrich K; Mesters, Rolf; Rühle, Frank; Stoll, Monika; Steppat, Dagmar; Kowalski, Dorothee; Rocke, Angela; Kuta, Piotr; Bajorat, Tido; Torge, Antje; Neuner, Bruno; Junker, Ralf; Nowak-Göttl, Ulrike.
Afiliación
  • Limperger V; UKSH, Institute of Clinical Chemistry, Hemostasis Unit, Arnold-Heller-Str. 3 Building 17, Kiel, 24105, Germany. verena.limperger@gmail.com.
  • Kenet G; National Hemophilia Center, Institute of Thrombosis and Hemostasis, Sheba Medical Centre, Tel-Hashomer, Israel.
  • Kiesau B; The Amalia Biron Research Institute of Thrombosis & Hemostasis, Tel Aviv University, Tel Aviv, Israel.
  • Köther M; UKSH, Institute of Clinical Chemistry, Hemostasis Unit, Arnold-Heller-Str. 3 Building 17, Kiel, 24105, Germany.
  • Schmeiser M; UKSH, Institute of Clinical Chemistry, Hemostasis Unit, Arnold-Heller-Str. 3 Building 17, Kiel, 24105, Germany.
  • Langer F; UKSH, Institute of Clinical Chemistry, Hemostasis Unit, Arnold-Heller-Str. 3 Building 17, Kiel, 24105, Germany.
  • Juhl D; Department of Hematology & Oncology, Univ. Hospital Hamburg, Hamburg, Germany.
  • Shneyder M; Institute of Transfusion Medicine, Univ. Hospital Kiel & Lübeck, Lübeck, Germany.
  • Franke A; UKSH, Institute of Clinical Chemistry, Hemostasis Unit, Arnold-Heller-Str. 3 Building 17, Kiel, 24105, Germany.
  • Klostermeier UK; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
  • Mesters R; UKSH, Institute of Clinical Chemistry, Hemostasis Unit, Arnold-Heller-Str. 3 Building 17, Kiel, 24105, Germany.
  • Rühle F; Department of Medicine/ Hematology & Oncology, Univ. Hospital Münster, Münster, Germany.
  • Stoll M; Institute of Human Genetics, Westfälische-Wilhelms-University, Münster, Germany.
  • Steppat D; Institute of Human Genetics, Westfälische-Wilhelms-University, Münster, Germany.
  • Kowalski D; Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
  • Rocke A; Institute of Transfusion Medicine, Univ. Hospital Kiel & Lübeck, Lübeck, Germany.
  • Kuta P; UKSH, Institute of Clinical Chemistry, Hemostasis Unit, Arnold-Heller-Str. 3 Building 17, Kiel, 24105, Germany.
  • Bajorat T; UKSH, Institute of Clinical Chemistry, Hemostasis Unit, Arnold-Heller-Str. 3 Building 17, Kiel, 24105, Germany.
  • Torge A; UKSH, Institute of Clinical Chemistry, Hemostasis Unit, Arnold-Heller-Str. 3 Building 17, Kiel, 24105, Germany.
  • Neuner B; UKSH, Institute of Clinical Chemistry, Hemostasis Unit, Arnold-Heller-Str. 3 Building 17, Kiel, 24105, Germany.
  • Junker R; UKSH, Institute of Clinical Chemistry, Hemostasis Unit, Arnold-Heller-Str. 3 Building 17, Kiel, 24105, Germany.
  • Nowak-Göttl U; Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Campus Charité Mitte and Campus Virchow-Klinikum, Berlin, Germany.
J Thromb Thrombolysis ; 51(2): 494-501, 2021 Feb.
Article en En | MEDLINE | ID: mdl-32594420
The role of the A>G polymorphism at position 19911 in the prothrombin gene (factor [F] 2 at rs3136516) as a risk factor for venous thromboembolism [VTE] is still unclear. To evaluate the presence of the F2 polymorphism in VTE patients compared to healthy blood donors and to adjust the results for common inherited thrombophilias [IT], age at onset and blood group [BG], and to calculate the risk of VTE recurrence. We investigated 1012 Caucasian patients with a diagnosis of VTE for the presence of the F2 rs3136516 polymorphism and compared these with 902 healthy blood donors. Odds ratios [OR] together with their 95% confidence intervals were calculated adjusted for F5 at rs6025, F2 at rs1799963, blood group, age and gender. In addition, we evaluated the risk of recurrent VTE during patient follow-up calculating hazard ratios [HR] together with their 95% CI. Compared with the AA wildtype, the F2 GG and AG genotypes (rs3136516) were associated with VTE (OR 1.48 and 1.45). The OR in F5 carriers compared to controls was 5.68 and 2.38 in patients with F2 (rs1799963). BG "non-O" was significantly more often diagnosed in patients compared to BG "O" (OR 2.74). VTE recurrence more often occurred in males (HR 2.3) and in carriers with combined thrombophilia (HR 2.11). Noteworthy, the rs3136516 polymorphism alone was not associated significantly with recurrence. In Caucasian patients with VTE the F2 GG/GA genotypes (rs3136516) were moderate risk factors for VTE. Recurrence was associated with male gender and combined thrombophilia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antígenos de Grupos Sanguíneos / Protrombina / Polimorfismo de Nucleótido Simple / Tromboembolia Venosa Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Thromb Thrombolysis Asunto de la revista: ANGIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antígenos de Grupos Sanguíneos / Protrombina / Polimorfismo de Nucleótido Simple / Tromboembolia Venosa Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Thromb Thrombolysis Asunto de la revista: ANGIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos