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Numbers of Axons in Spared Neural Tissue Bridges But Not Their Widths or Areas Correlate With Functional Recovery in Spinal Cord-Injured Rats.
Rink, Svenja; Pavlov, Stoyan; Wöhler, Aliona; Bendella, Habib; Manthou, Marilena; Papamitsou, Theodora; Dunlop, Sarah A; Angelov, Doychin N.
Afiliación
  • Rink S; Department of Prosthetic Dentistry, School of Dental and Oral Medicine, University of Cologne, Germany.
  • Pavlov S; Department of Anatomy, Histology and Embryology, Medical University, Varna, Bulgaria.
  • Wöhler A; Department of Anatomy I, University of Cologne.
  • Bendella H; Department of Neurosurgery, University of Witten/Herdecke, Cologne Merheim Medical Center (CMMC), Cologne, Germany.
  • Manthou M; Department of Histology and Embryology, Aristotle University Thessaloniki, Greece.
  • Papamitsou T; Department of Histology and Embryology, Aristotle University Thessaloniki, Greece.
  • Dunlop SA; School of Biological Sciences, The University of Western Australia, Australia.
  • Angelov DN; Department of Anatomy I, University of Cologne.
J Neuropathol Exp Neurol ; 79(11): 1203-1217, 2020 11 01.
Article en En | MEDLINE | ID: mdl-32594136
The relationships between various parameters of tissue damage and subsequent functional recovery after spinal cord injury (SCI) are not well understood. Patients may regain micturition control and walking despite large postinjury medullar cavities. The objective of this study was to establish possible correlations between morphological findings and degree of functional recovery after spinal cord compression at vertebra Th8 in rats. Recovery of motor (Basso, Beattie, Bresnahan, foot-stepping angle, rump-height index, and ladder climbing), sensory (withdrawal latency), and bladder functions was analyzed at 1, 3, 6, 9, and 12 weeks post-SCI. Following perfusion fixation, spinal cord tissue encompassing the injury site was cut in longitudinal frontal sections. Lesion lengths, lesion volumes, and areas of perilesional neural tissue bridges were determined after staining with cresyl violet. The numbers of axons in these bridges were quantified after staining for class III ß-tubulin. We found that it was not the area of the spared tissue bridges, which is routinely determined by magnetic resonance imaging (MRI), but the numbers of axons in them that correlated with functional recovery after SCI (Spearman's ρ > 0.8; p < 0.001). We conclude that prognostic statements based only on MRI measurements should be considered with caution.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Axones / Recuperación de la Función Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Neuropathol Exp Neurol Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Axones / Recuperación de la Función Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Neuropathol Exp Neurol Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido