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Social Distancing Alters the Clinical Course of COVID-19 in Young Adults: A Comparative Cohort Study.
Bielecki, Michel; Züst, Roland; Siegrist, Denise; Meyerhofer, Daniele; Crameri, Giovanni Andrea Gerardo; Stanga, Zeno; Stettbacher, Andreas; Buehrer, Thomas Werner; Deuel, Jeremy Werner.
Afiliación
  • Bielecki M; Swiss Armed Forces, Medical Services, Ittigen, Switzerland.
  • Züst R; Swiss Armed Forces, Sanitary Medical School, Airolo, Switzerland.
  • Siegrist D; University of Zurich, Institute for Epidemiology, Biostatistics and Prevention Institute, Travel Clinic, Zurich, Switzerland.
  • Meyerhofer D; Federal Office for Civil Protection, Spiez Laboratory, Spiez, Switzerland.
  • Crameri GAG; Federal Office for Civil Protection, Spiez Laboratory, Spiez, Switzerland.
  • Stanga Z; Swiss Armed Forces, Sanitary Medical School, Airolo, Switzerland.
  • Stettbacher A; Swiss Armed Forces, Medical Services, Ittigen, Switzerland.
  • Buehrer TW; Swiss Armed Forces, Medical Services, Ittigen, Switzerland.
  • Deuel JW; Department of Diabetes, Endocrinology, Nutritional Medicine, and Metabolism, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Clin Infect Dis ; 72(4): 598-603, 2021 02 16.
Article en En | MEDLINE | ID: mdl-32594121
BACKGROUND: Social distancing and stringent hygiene seem to be effective in reducing the number of transmitted virus particles, and therefore the infectivity, of coronavirus disease 2019 (COVID-19) and could alter the mode of transmission of the disease. However, it is not known if such practices can change the clinical course in infected individuals. METHODS: We prospectively studied an outbreak of COVID-19 in Switzerland among a population of 508 predominantly male soldiers with a median age of 21 years. We followed the number of infections in 2 spatially separated cohorts with almost identical baseline characteristics with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) before and after implementation of stringent social distancing. RESULTS: Of the 354 soldiers infected prior to the implementation of social distancing, 30% fell ill from COVID-19, while no soldier in a group of 154, in which infections appeared after implementation of social distancing, developed COVID-19 despite the detection of viral RNA in the nasal and virus-specific antibodies within this group. CONCLUSIONS: Social distancing not only can slow the spread of SARS-CoV-2 in a cohort of young, healthy adults but it can also prevent the outbreak of COVID-19 while still inducing an immune response and colonizing nasal passages. Viral inoculum during infection or mode of transmission may be a key factor determining the clinical course of COVID-19.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Distanciamiento Físico / COVID-19 Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2021 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Distanciamiento Físico / COVID-19 Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Humans / Male País/Región como asunto: Europa Idioma: En Revista: Clin Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2021 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos