Your browser doesn't support javascript.
loading
Life Course Trajectories of Maternal Cardiovascular Risk Factors according to Offspring Birthweight: The HUNT Study.
Horn, Julie; Haug, Eirin B; Markovitz, Amanda R; Fraser, Abigail; Vatten, Lars J; Romundstad, Pål R; Rich-Edwards, Janet W; Åsvold, Bjørn O.
Afiliación
  • Horn J; Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway. Julie.Horn@ntnu.no.
  • Haug EB; Department of Obstetrics and Gynecology, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway. Julie.Horn@ntnu.no.
  • Markovitz AR; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
  • Fraser A; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Vatten LJ; Division of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Romundstad PR; Mathematica Policy Research, Cambridge, MA, USA.
  • Rich-Edwards JW; MRC Integrative Epidemiology Unit and School of Social and Community Medicine, University of Bristol, Bristol, UK.
  • Åsvold BO; Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
Sci Rep ; 10(1): 10436, 2020 06 26.
Article en En | MEDLINE | ID: mdl-32591565
Women with small or large for gestational age offspring are at increased risk of cardiovascular disease later in life. How their cardiovascular risk factors develop across the life course is incompletely known. We linked data from the population-based HUNT Study (1984-2008) and the Medical Birth Registry of Norway (1967-2012) for 22,487 women. Mixed effect models were used to compare cardiovascular risk factor trajectories for women according to first offspring birthweight for gestational age. Women with small for gestational age (SGA) offspring had 1-2 mmHg higher systolic and diastolic blood pressure across the life course, but lower measures of adiposity, compared to women with offspring who were appropriate for gestational age (AGA). In contrast, women with large for gestational age (LGA) offspring had higher measures of adiposity, ~0.1 mmol/l higher non-HDL cholesterol and triglycerides and 0.2 mmol/l higher non-fasting glucose, compared with mothers of AGA offspring. These differences were broadly stable from prior to first pregnancy until 60 years of age. Our findings point to different cardiovascular risk profiles in mothers of SGA versus LGA offspring, where giving birth to SGA offspring might primarily reflect adverse maternal vascular health whereas LGA offspring might reflect the mother's metabolic health.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones del Embarazo / Enfermedades Cardiovasculares / Adiposidad / Madres Tipo de estudio: Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged / Pregnancy Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones del Embarazo / Enfermedades Cardiovasculares / Adiposidad / Madres Tipo de estudio: Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged / Pregnancy Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido