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Low dose computed tomography of the lung for detection and grading of interstitial lung disease: A systematic simulation study.
Ley, S; Fidler, L; Schenk, H; Durand, M; Marras, T; Paul, N; Shapera, S; Mittoo, S.
Afiliación
  • Ley S; Surgical Clinic Munich South, Munich, Bavaria, Germany; Joint Department of Medical Imaging, Toronto General Hospital, Toronto, Ontario, Canada; Institute of Clinical Radiology, Ludwig Maximilians University, Munich, Germany. Electronic address: ley@gmx.net.
  • Fidler L; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Schenk H; Surgical Clinic Munich South, Munich, Bavaria, Germany.
  • Durand M; Department of Radiology, Grey's Hospital, Pietermaritzburg, KwaZulu-Natal, South Africa; Joint Department of Medical Imaging, Toronto General Hospital, Toronto, Ontario, Canada.
  • Marras T; Department of Respirology, Toronto Western Hospital, Toronto, Ontario, Canada.
  • Paul N; Joint Department of Medical Imaging, Toronto General Hospital, Toronto, Ontario, Canada.
  • Shapera S; Department of Respirology, Toronto General Hospital, Toronto, Ontario, Canada.
  • Mittoo S; Department of Rheumatology, Mount Sinai Hospital, Toronto, Ontario, Canada.
Pulmonology ; 27(1): 14-25, 2021.
Article en En | MEDLINE | ID: mdl-32591280
PURPOSE: HRCT is the preferred imaging technique to evaluate Interstitial-Lung-Disease. Optimal Low-Dose-Computed-Tomography protocol for monitoring ILD with lowest radiation dose and optimal diagnostic accuracy and image quality unknown. METHODS: 28 Patients underwent HRCT. Image reconstructions with varying combinations of tube current (50mA, 20mA, 15 mA, 10mA) and image-thickness/increment (1/1mm, 2/2mm, 3/2.4mm, 5/4mm) were simulated from raw data. 448 CTs evaluated by 2 readers on image quality and ILD-specific features (ground glass opacification (ggo), honeycombing (hc), reticulation (ret)). RESULTS: Reduced dose settings with 20 mA did not show any significant difference to standard dose settings for all parameters in reader 1, while results were significantly altered in reader 2. Slice thickness did not significantly influence rating of typical ILD features like ggo, hc, ret or total disease extent. The correct differentiation between UIP and NSIP could be made on all dose settings and with all slice thickness. It was even found, that an increased slice thickness can compensate for the noise associated image quality degradation. Overall, for ggo detection a combination of 20 mA and 3 or 5 mm slice thickness was not different to the original evaluation. CONCLUSIONS: Assessment of ILD specific CT features down to 20 mA and a slice thickness of 3 or 5 mm is feasible.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Simulación por Computador / Tomografía Computarizada por Rayos X / Enfermedades Pulmonares Intersticiales / Pulmón Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Pulmonology Año: 2021 Tipo del documento: Article Pais de publicación: España
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Simulación por Computador / Tomografía Computarizada por Rayos X / Enfermedades Pulmonares Intersticiales / Pulmón Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Pulmonology Año: 2021 Tipo del documento: Article Pais de publicación: España