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Serotonin Expression in the Song Circuitry of Adult Male Zebra Finches.
Yip, Ping K; Schmitzberger, Magdalena; Al-Hasan, Mohammed; George, Julia; Tripoliti, Elina; Michael-Titus, Adina T; Clayton, David; Priestley, John V.
Afiliación
  • Yip PK; Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, 4 Newark St, London E1 2AT, UK. Electronic address: p.yip@qmul.ac.uk.
  • Schmitzberger M; Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, 4 Newark St, London E1 2AT, UK.
  • Al-Hasan M; Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, 4 Newark St, London E1 2AT, UK.
  • George J; Queen Mary University of London, School of Biological and Chemical Sciences, G.E. Fogg Building, Mile End Road, London E1 4NS, UK.
  • Tripoliti E; UCL, Institute of Neurology, Department of Movement and Clinical Neurosciences, 33 Queen Square, London WC1N 3BG, UK.
  • Michael-Titus AT; Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, 4 Newark St, London E1 2AT, UK.
  • Clayton D; Queen Mary University of London, School of Biological and Chemical Sciences, G.E. Fogg Building, Mile End Road, London E1 4NS, UK.
  • Priestley JV; Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute, 4 Newark St, London E1 2AT, UK.
Neuroscience ; 444: 170-182, 2020 09 15.
Article en En | MEDLINE | ID: mdl-32590039
Serotonin is an important neurotransmitter of the brain, but its role in song control remains to be fully demonstrated. Using male zebra finches (Taeniopygia guttata) that have song learning and production capabilities, we analysed the serotonin expression levels in the song nuclei and adjacent areas (peri-song nuclei) using immunohistochemistry. Key song nuclei were identified using combinations of Hoechst, choline acetyltransferase, and a neurofilament (NN18) marker in reference to the ZEBrA atlas. Mean serotonin expression was highest in interfacial nucleus (Nif) and lower in the other song nuclei in the following order (in order of highest first): interfacial nucleus (Nif) > Area X > dorsomedial part of the intercollicular nucelus (DM) > robust nucleus of the archistriatum (RA) > lateral magnocellular nucleus of the anterior neostriatum (LMAN) > ventral respiratory group (VRG) > dorsolateral nucleus of the medial thalamus (DLM) > the nucleus HVC (proper name) > tracheosyringeal motor nucleus (nXIIts). However, the mean serotonin expression (in order of highest first) in the peri-song nuclei regions was: peri-DM > peri-nXIIts > supra-peri-HVC > peri-RA > peri-DLM > peri-Area X > infra-peri-HVC > peri-VRG > peri-LMAN > peri-Nif. Interestingly, serotoninergic fibers immunostained for serotonin or the serotonin transporter can be found as a basket-like peri-neuronal structure surrounding cholinergic cell bodies, and appear to form contacts onto dopaminergic neurones. In summary, serotonin fibers are present at discrete song nuclei, and peri-song nuclei regions, which suggest serotonin may have a direct and/or modulatory role in song control.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vocalización Animal / Pinzones Límite: Animals Idioma: En Revista: Neuroscience Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vocalización Animal / Pinzones Límite: Animals Idioma: En Revista: Neuroscience Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos