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Inner retinal layer thinning in radiologically isolated syndrome predicts conversion to multiple sclerosis.
Aly, L; Havla, J; Lepennetier, G; Andlauer, T F M; Sie, C; Strauß, E-M; Hoshi, M-M; Kümpfel, T; Hiltensperger, M; Mitsdoerffer, M; Mühlau, M; Zimmer, C; Hemmer, B; Korn, T; Knier, B.
Afiliación
  • Aly L; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Havla J; Institute of Experimental Neuroimmunology, Technical University of Munich, Munich, Germany.
  • Lepennetier G; Institute of Clinical Neuroimmunology, Ludwig-Maximilians University, Munich, Germany.
  • Andlauer TFM; Data Integration for Future Medicine (DIFUTURE) Consortium, Technical University of Munich and Ludwig-Maximilians University, Munich, Germany.
  • Sie C; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Strauß EM; Institute of Experimental Neuroimmunology, Technical University of Munich, Munich, Germany.
  • Hoshi MM; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Kümpfel T; Institute of Experimental Neuroimmunology, Technical University of Munich, Munich, Germany.
  • Hiltensperger M; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Mitsdoerffer M; Institute of Experimental Neuroimmunology, Technical University of Munich, Munich, Germany.
  • Mühlau M; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Zimmer C; Marianne-Strauß-Klinik, Berg, Germany.
  • Hemmer B; Institute of Clinical Neuroimmunology, Ludwig-Maximilians University, Munich, Germany.
  • Korn T; Institute of Experimental Neuroimmunology, Technical University of Munich, Munich, Germany.
  • Knier B; Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Eur J Neurol ; 27(11): 2217-2224, 2020 11.
Article en En | MEDLINE | ID: mdl-32589804
BACKGROUND AND PURPOSE: Individuals with radiologically isolated syndrome (RIS) are at increased risk of converting to multiple sclerosis (MS). Early identification of later converters is crucial for optimal treatment decisions. The purpose of this study was to assess the predictive potential of optical coherence tomography (OCT) measures in individuals with RIS regarding conversion to MS. METHODS: This prospective observational cohort study included 36 individuals with RIS and 36 healthy controls recruited from two German MS centers. All individuals received baseline OCT and clinical examination and were longitudinally followed over up to 6 years. The primary outcome measure was the conversion to MS. RESULTS: During clinical follow-up of 46 (26-58) months (median, 25%-75% interquartile range), eight individuals with RIS converted to MS. Individuals converting to MS showed a thinning of the peripapillary retinal nerve fiber layer (pRNFL) and the common ganglion cell and inner plexiform layer (GCIP) at baseline and during follow-up. Individuals with a pRNFL of 99 µm or lower or a GCIP of 1.99 mm3 or lower were at a 7.5- and 8.0-fold risk for MS conversion, respectively, compared to individuals with higher measures. After correction for other known risk factors, Cox proportional hazards regression revealed a hazard ratio of 1.08 for conversion to MS for each 1 µm decline in pRNFL. CONCLUSIONS: Reduction of the pRNFL might be a novel and independent risk factor for conversion to MS in individuals with RIS. OCT might be useful for risk stratification and therapeutic decision-making in individuals with RIS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Desmielinizantes / Esclerosis Múltiple Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Desmielinizantes / Esclerosis Múltiple Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido