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Front-Line Therapy for Elderly Chronic Lymphocytic Leukemia Patients: Bendamustine Plus Rituximab or Chlorambucil Plus Rituximab? Real-Life Retrospective Multicenter Study in the Lazio Region.
Autore, Francesco; Innocenti, Idanna; Corrente, Francesco; Del Principe, Maria Ilaria; Rosati, Serena; Falcucci, Paolo; Fresa, Alberto; Conte, Esmeralda; Limongiello, Maria Assunta; Renzi, Daniela; De Padua, Laura; Andriani, Alessandro; Pisani, Francesco; Cimino, Giuseppe; Tafuri, Agostino; Montanaro, Marco; Mauro, Francesca Romana; Del Poeta, Giovanni; Laurenti, Luca.
Afiliación
  • Autore F; Institute of Hematology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
  • Innocenti I; Institute of Hematology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
  • Corrente F; Institute of Hematology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
  • Del Principe MI; Hematology Unit, Department of Biomedicine and Prevention, University tor Vergata of Rome, Rome, Italy.
  • Rosati S; Hematology Unit, Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy.
  • Falcucci P; Division of Hematology, Ospedale Belcolle, Viterbo, Italy.
  • Fresa A; Institute of Hematology, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Conte E; Hematology Unit, Azienda Ospedaliera-Universitaria Sant'Andrea, Rome, Italy.
  • Limongiello MA; Hematology Unit, Ospedale Santa Maria Goretti, Latina, Italy.
  • Renzi D; Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
  • De Padua L; Hematology Unit, Fabrizio Spaziani Hospital, Frosinone, Italy.
  • Andriani A; Hematology Unit, Fabrizio Spaziani Hospital, Frosinone, Italy.
  • Pisani F; Hematology and Stem Cell Transplant Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
  • Cimino G; Hematology Unit, Ospedale Santa Maria Goretti, Latina, Italy.
  • Tafuri A; Hematology Unit, Azienda Ospedaliera-Universitaria Sant'Andrea, Rome, Italy.
  • Montanaro M; Division of Hematology, Ospedale Belcolle, Viterbo, Italy.
  • Mauro FR; Hematology Unit, Department of Cellular Biotechnologies and Hematology, Sapienza University, Rome, Italy.
  • Del Poeta G; Hematology Unit, Department of Biomedicine and Prevention, University tor Vergata of Rome, Rome, Italy.
  • Laurenti L; Institute of Hematology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Front Oncol ; 10: 848, 2020.
Article en En | MEDLINE | ID: mdl-32587827
Previous studies investigated the efficacy and the safety of bendamustine (B) vs. chlorambucil (Chl) associated with rituximab (R) in fludarabine-ineligible patients with treated and untreated chronic lymphocytic leukemia (CLL). We conducted a retrospective multicenter study in the Lazio region to further evaluate and compare the efficacy and the toxicity of Chl-R and B-R regimen in CLL patients over the age of 65. We enrolled 192 untreated CLL patients: 111 treated with B-R and 81 with Chl-R. The overall response rates (ORR; 93.6% in B-R and 86.5% in Chl-R) were not statistically different between the two groups, such as progression-free survival (PFS), time to retreatment (TTR), and overall survival (OS). The B-R group showed a higher hematological (p = 0.007) and extra-hematological (p = 0.008) toxicity. When comparing the toxicities according to age, we noted that the extra-hematological toxicity was higher in patients over the age of 75 who were treated with B-R than those treated with Chl-R (p = 0.03). This retrospective study confirms the feasibility of B-R and Chl-R in elderly untreated CLL patients. Currently, patients who are over 75 and unfit are usually treated with Chl-R. This scheme allows achieving the same ORR, PFS, TTR, and OS when compared with B-R because of hematological and extra-hematological toxicities due to B, in which a greater dose reduction has been shown in comparison to Chl.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Idioma: En Revista: Front Oncol Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies Idioma: En Revista: Front Oncol Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza