The WD40-repeat protein WDR-48 promotes the stability of the deubiquitinating enzyme USP-46 by inhibiting its ubiquitination and degradation.

Hodul, Molly; Ganji, Rakesh; Dahlberg, Caroline L; Raman, Malavika; Juo, Peter

Hodul, Molly; Ganji, Rakesh; Dahlberg, Caroline L; Raman, Malavika; Juo, Peter.

Afiliación

Hodul M; Graduate Program in Neuroscience, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts, USA.
Ganji R; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Dahlberg CL; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Raman M; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Juo P; Department of Biology, Western Washington University, Bellingham, Washington, USA.

J Biol Chem ; 295(33): 11776-11788, 2020 08 14.

Article en En | MEDLINE | ID: mdl-32587090

Asunto(s)

Caenorhabditis elegans/metabolismo; Animales; Caenorhabditis elegans/química; Estabilidad de Enzimas; Células HEK293; Humanos; Proteolisis; Ubiquitinación; Repeticiones WD40

Palabras clave

Caenorhabditis elegans (C. elegans); USP-12; USP-46; WD40-repeat; WDR; WDR48; cell biology; deubiquitinating enzyme (DUB); neurobiology; post-translational modification; post-translational modification (PTM); proteasome; protein degradation; protein homeostasis; regulation; ubiquitin; ubiquitin-specific peptidase 46

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caenorhabditis elegans Límite: Animals / Humans Idioma: En Revista: J Biol Chem Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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