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Effects of gastric sleeve surgery on the serum levels of GH, IGF-1 and IGF-binding protein 2 in healthy obese patients.
Al-Regaiey, Khalid; Alshubrami, Suad; Al-Beeshi, Ibrahim; Alnasser, Torki; Alwabel, Abdulnasser; Al-Beladi, Hassan; Al-Tujjar, Omar; Alnasser, Abdulrahman; Alfadda, Assim A; Iqbal, Muhammad.
Afiliación
  • Al-Regaiey K; Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
  • Alshubrami S; Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
  • Al-Beeshi I; Current Address: Director of Academic and Training Affairs Continuous Professional, King Salman Specialist Hospital, Hail, Saudi Arabia.
  • Alnasser T; Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
  • Alwabel A; Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
  • Al-Beladi H; Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
  • Al-Tujjar O; Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
  • Alnasser A; Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
  • Alfadda AA; Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
  • Iqbal M; Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
BMC Gastroenterol ; 20(1): 199, 2020 Jun 25.
Article en En | MEDLINE | ID: mdl-32586279
BACKGROUND: Bariatric surgery is an effective treatment for severe obesity. It also ameliorates diabetes independently of weight loss through mechanisms that are not fully understood. In this study, we investigated the levels of GH, IGF-1 and IGF-binding protein 2 (IGFBP-2) after gastric sleeve surgery in healthy obese individuals. METHOD: This study was conducted in 33 obese (BMI > 38.3) healthy male subjects aged 25 to 50 years undergoing sleeve gastrectomy. GH, IGF-1 and IGFBP-2 levels were evaluated by ELISA at baseline and 6-12 months after surgery. Other parameters, such as glucose, BMI, insulin, HOMA-IR and lipid profile, were also investigated. RESULTS: Systemic GH (12.32 vs. 50.97 pg/mL, p < 0.001) and IGFBP-2 levels (51.86 vs. 68.81 pg/mL, p < 0.001) were elevated after bariatric surgery. There was no change in IGF-1 level from before to after surgery. BMI (52.18 vs. 40.11, p = 0.001), insulin (19.35 vs. 8.80 mIU/L, p < 0.001) and HOMA-IR index (6.48 to 2.52, p < 0.001) were reduced after surgery. Lipid profile analysis revealed that total cholesterol (4.26 vs. 5.12 mmol/L, p < 0.001) and high-density lipoprotein (HDL) (0.90 to 1.55 mmol/L, p < 0.001) were increased, while triglycerides were decreased, after surgery (1.62 vs. 1.05 mmol/L p < 0.001). GH, IGF-1, and IGFBP-2 were not correlated with insulin or lipid parameters. CONCLUSIONS: Our study suggests that improved circulating GH and IGFBP-2 levels may mediate the beneficial effects of gastric sleeve surgery in improving insulin sensitivity and reducing insulin demand.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor I del Crecimiento Similar a la Insulina / Proteína 2 de Unión a Factor de Crecimiento Similar a la Insulina Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: BMC Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Factor I del Crecimiento Similar a la Insulina / Proteína 2 de Unión a Factor de Crecimiento Similar a la Insulina Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: BMC Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Reino Unido