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IMPACT OF COMORBIDITIES IN MEXICAN SARS-COV-2-POSITIVE PATIENTS: A RETROSPECTIVE ANALYSIS IN A NATIONAL COHORT.
Kammar-García, Ashuin; Vidal-Mayo, José de J; Vera-Zertuche, Juan M; Lazcano-Hernández, Martín; Vera-López, Obdulia; Segura-Badilla, Orietta; Aguilar-Alonso, Patricia; Navarro-Cruz, Addi R.
Afiliación
  • Kammar-García A; Emergency Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ), Mexico City, Mexico.
  • Vidal-Mayo JJ; Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, Mexico.
  • Vera-Zertuche JM; Emergency Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ), Mexico City, Mexico.
  • Lazcano-Hernández M; Department of Endocrinology, Obesity Clinic, INCMNSZ, Mexico City, Mexico.
  • Vera-López O; Deparment of Biochemistry and Foods, Faculty of Chemical Sciences, Benemérita Universidad Autónoma de Puebla, Pue., Mexico.
  • Segura-Badilla O; Deparment of Biochemistry and Foods, Faculty of Chemical Sciences, Benemérita Universidad Autónoma de Puebla, Pue., Mexico.
  • Aguilar-Alonso P; Department of Nutrition and Public Health, Faculty of Health and Food Sciences, "Programa Universidad Bío-Bío (UBB) Saludable," Universidad del Bío-Bío, Concepción, Chile.
  • Navarro-Cruz AR; Deparment of Biochemistry and Foods, Faculty of Chemical Sciences, Benemérita Universidad Autónoma de Puebla, Pue., Mexico.
Rev Invest Clin ; 72(3): 151-158, 2020.
Article en En | MEDLINE | ID: mdl-32584330
BACKGROUND: The coronavirus disease 2019 outbreak is a significant challenge for health-care systems around the world. OBJECTIVE: The objective of the study was to assess the impact of comorbidities on the case fatality rate (CFR) and the development of adverse events in patients positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the Mexican population. MATERIALS AND METHODS: We analyzed the data from 13,842 laboratory-confirmed SARS-CoV-2 patients in Mexico between January 1, 2020, and April 25, 2020. We investigated the risk of death and the development of adverse events (hospitalization, pneumonia, orotracheal intubation, and intensive care unit [ICU] admission), comparing the number of comorbidities of each patient. RESULTS: The patient mean age was 46.6 ± 15.6 years, 42.3% (n = 5853) of the cases were women, 38.8% of patients were hospitalized, 4.4% were intubated, 29.6% developed pneumonia, and 4.4% had critical illness. The CFR was 9.4%. The risk of hospitalization (odds ratio [OR] = 3.1, 95% confidence interval [CI]: 2.7-3.7), pneumonia (OR = 3.02, 95% CI: 2.6-3.5), ICU admission (OR = 2, 95% CI: 1.5-2.7), and CFR (hazard ratio = 3.5, 95% CI: 2.9-4.2) was higher in patients with three or more comorbidities than in patients with 1, 2, or with no comorbidities. CONCLUSIONS: The number of comorbidities may be a determining factor in the clinical course and its outcomes in SARS-CoV-2-positive patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Viral / Infecciones por Coronavirus / Pandemias / Betacoronavirus Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged / Pregnancy País/Región como asunto: Mexico Idioma: En Revista: Rev Invest Clin Asunto de la revista: MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: México Pais de publicación: México
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Viral / Infecciones por Coronavirus / Pandemias / Betacoronavirus Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged / Pregnancy País/Región como asunto: Mexico Idioma: En Revista: Rev Invest Clin Asunto de la revista: MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: México Pais de publicación: México