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Two Episodes of Transfusion-related Acute Lung Injury (TRALI) Occurring within a Short Period.
Akagi, Yuina; Murata, Shogo; Yamashita, Yusuke; Tanaka, Ken; Hiroi, Takayuki; Mushino, Toshiki; Hosoi, Hiroki; Nishikawa, Akinori; Tamura, Shinobu; Sonoki, Takashi.
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  • Akagi Y; Department of Hematology/Oncology, Wakayama Medical University, Japan.
  • Murata S; Department of Hematology/Oncology, Wakayama Medical University, Japan.
  • Yamashita Y; Department of Hematology/Oncology, Wakayama Medical University, Japan.
  • Tanaka K; Department of Hematology/Oncology, Wakayama Medical University, Japan.
  • Hiroi T; Department of Hematology/Oncology, Wakayama Medical University, Japan.
  • Mushino T; Department of Hematology/Oncology, Wakayama Medical University, Japan.
  • Hosoi H; Department of Hematology/Oncology, Wakayama Medical University, Japan.
  • Nishikawa A; Department of Hematology/Oncology, Wakayama Medical University, Japan.
  • Tamura S; Department of Hematology/Oncology, Wakayama Medical University, Japan.
  • Sonoki T; Department of Hematology/Oncology, Wakayama Medical University, Japan.
Intern Med ; 59(20): 2577-2581, 2020 Oct 15.
Article en En | MEDLINE | ID: mdl-32581159
Transfusion-related acute lung injury (TRALI) is a non-hemolytic adverse reaction that occurs ≤6 hours after receiving a transfusion. A 72-year-old man with leukemia developed severe hypoxemia after platelet transfusions on two occasions within a 4-day period. During the first episode, the transfused platelet preparation was positive for anti-human-leukocyte antigen antibodies. The pathogenesis of TRALI includes an antibody-mediated mechanism and a non-antibody-mediated mechanism, in which various factors combine to activate pulmonary neutrophils. In our case, it is considered that the patient's neutrophils reached the activation threshold for the development of TRALI after the accumulation of various factors besides anti-leukocyte antibodies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia / Transfusión de Plaquetas / Lesión Pulmonar Aguda Postransfusional Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Aged / Humans / Male Idioma: En Revista: Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia / Transfusión de Plaquetas / Lesión Pulmonar Aguda Postransfusional Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Aged / Humans / Male Idioma: En Revista: Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón