Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity.

Fultang, Livingstone; Booth, Sarah; Yogev, Orli; Martins da Costa, Barbara; Tubb, Vanessa; Panetti, Silvia; Stavrou, Victoria; Scarpa, Ugo; Jankevics, Andris; Lloyd, Gavin; Southam, Andrew; Lee, Steven P; Dunn, Warwick B; Chesler, Louis; Mussai, Francis; De Santo, Carmela

Fultang, Livingstone; Booth, Sarah; Yogev, Orli; Martins da Costa, Barbara; Tubb, Vanessa; Panetti, Silvia; Stavrou, Victoria; Scarpa, Ugo; Jankevics, Andris; Lloyd, Gavin; Southam, Andrew; Lee, Steven P; Dunn, Warwick B; Chesler, Louis; Mussai, Francis; De Santo, Carmela.

Afiliación

Fultang L; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Booth S; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Yogev O; The Institute of Cancer Research, London, United Kingdom; and.
Martins da Costa B; The Institute of Cancer Research, London, United Kingdom; and.
Tubb V; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Panetti S; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Stavrou V; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Scarpa U; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Jankevics A; School of Biosciences and Phenome Centre Birmingham and.
Lloyd G; School of Biosciences and Phenome Centre Birmingham and.
Southam A; School of Biosciences and Phenome Centre Birmingham and.
Lee SP; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Dunn WB; School of Biosciences and Phenome Centre Birmingham and.
Chesler L; The Institute of Cancer Research, London, United Kingdom; and.
Mussai F; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
De Santo C; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.

Blood ; 136(10): 1155-1160, 2020 09 03.

Article en En | MEDLINE | ID: mdl-32573723

Asunto(s)

Arginina/metabolismo; Argininosuccinato Sintasa/metabolismo; Inmunoterapia Adoptiva/métodos; Leucemia Mieloide Aguda/terapia; Neuroblastoma/terapia; Ornitina Carbamoiltransferasa/metabolismo; Linfocitos T/trasplante; Animales; Apoptosis; Argininosuccinato Sintasa/genética; Proliferación Celular; Humanos; Leucemia Mieloide Aguda/inmunología; Leucemia Mieloide Aguda/metabolismo; Leucemia Mieloide Aguda/patología; Ingeniería Metabólica/métodos; Ratones; Ratones Desnudos; Neuroblastoma/inmunología; Neuroblastoma/metabolismo; Neuroblastoma/patología; Ornitina Carbamoiltransferasa/genética; Receptores Quiméricos de Antígenos/química; Receptores Quiméricos de Antígenos/inmunología; Linfocitos T/inmunología; Linfocitos T/metabolismo; Células Tumorales Cultivadas; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ornitina Carbamoiltransferasa / Arginina / Argininosuccinato Sintasa / Linfocitos T / Leucemia Mieloide Aguda / Inmunoterapia Adoptiva / Neuroblastoma Límite: Animals / Humans Idioma: En Revista: Blood Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos

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