Your browser doesn't support javascript.
loading
High-risk human papillomavirus in patients with oral leukoplakia and oral squamous cell carcinoma-A multi-centre study in Sweden, Brazil and Romania.
Sundberg, Jonas; Öhman, Jenny; Korytowska, Magdalena; Wallström, Mats; Kjeller, Göran; Andersson, Maria; Horal, Peter; Lindh, Magnus; Giglio, Daniel; Kovács, Anikó; Sand, Lars; Hirsch, Jan-Michaél; Magda Araújo Ferracini, Lais; de Souza, Ana Carolina Mamana Fernandes; Parlatescu, Ioanina; Dobre, Maria; Hinescu, Mihail-Eugen; Braz-Silva, Paulo Henrique; Tovaru, Serban; Hasséus, Bengt.
Afiliación
  • Sundberg J; Department of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Öhman J; Department of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Korytowska M; Clinic of Oral Medicine, Public Dental Service, Region Västra Götaland, NÄL Hospital, Trollhättan, Sweden.
  • Wallström M; Department of Oral and Maxillofacial Surgery, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Kjeller G; Department of Oral and Maxillofacial Surgery, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Andersson M; Department of Infectious Medicine, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Horal P; Department of Infectious Medicine, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Lindh M; Department of Infectious Medicine, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Giglio D; Department of Oncology, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Kovács A; Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Sand L; Department of Oral Biology, Faculty of Odontology, University of Oslo, Oslo, Norway.
  • Hirsch JM; Department of Surgical Sciences, Oral and Maxillofacial Surgery, Uppsala University, Uppsala, Sweden.
  • Magda Araújo Ferracini L; Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
  • de Souza ACMF; Laboratory of Virology, School of Medicine, Institute of Tropical Medicine of São Paulo, São Paulo, Brazil.
  • Parlatescu I; Faculty of Dental Medicine, Oral Pathology Discipline, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
  • Dobre M; Victor Babes Institute of Pathology, Bucharest, Romania.
  • Hinescu ME; Faculty of Dental Medicine, Oral Pathology Discipline, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
  • Braz-Silva PH; Victor Babes Institute of Pathology, Bucharest, Romania.
  • Tovaru S; Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
  • Hasséus B; Laboratory of Virology, School of Medicine, Institute of Tropical Medicine of São Paulo, São Paulo, Brazil.
Oral Dis ; 27(2): 183-192, 2021 Mar.
Article en En | MEDLINE | ID: mdl-32568421
OBJECTIVES: Although causal associations between oral leukoplakia (OL), oral squamous cell carcinoma (OSCC) and high-risk human papillomavirus (HR-HPV) have been speculated upon in several reports, conclusive evidence has not been presented. This study investigates whether the number of cases of HR-HPV in OL has increased over time and whether the prevalence of HR-HPV-positive OL differs in various parts of the world. PATIENTS AND METHODS: A total of 432 patients with OL from Sweden, Brazil and Romania were analysed. Patients were divided into historical (1992-2002) and contemporary (2011-2017) cohorts from the respective countries. Seventeen patients with OL developed oral squamous cell carcinoma (OSCC). A real-time PCR assay, targeting HPV sub-types 6,11,16,18,31,33,35,39,45,52,56,58 and 59, was performed to detect HR-HPV in patients with OL. RESULTS: In the Swedish and Romanian cohorts, none of the investigated HPV sub-types were detected. In the Brazilian cohorts, five patients with OL (3%) were positive for HR-HPV, including four patients from the contemporary cohort (HPV 16, 31, 33) and one from the historical cohort (HPV 11). All the cases of OL that transformed into OSCC were HR-HPV-negative, as were the corresponding tumours. CONCLUSIONS: In summary, the prevalence of HR-HPV in OL is low in all the tested countries, and the incidence has not changed over time. HR-HPV in OL does not seem to be a driver of oncogenesis.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Papillomaviridae / Neoplasias de la Boca / Carcinoma de Células Escamosas / Infecciones por Papillomavirus / Neoplasias de Cabeza y Cuello Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Humans País/Región como asunto: America do sul / Brasil / Europa Idioma: En Revista: Oral Dis Asunto de la revista: ODONTOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Dinamarca
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Papillomaviridae / Neoplasias de la Boca / Carcinoma de Células Escamosas / Infecciones por Papillomavirus / Neoplasias de Cabeza y Cuello Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Humans País/Región como asunto: America do sul / Brasil / Europa Idioma: En Revista: Oral Dis Asunto de la revista: ODONTOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Dinamarca