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Acute retinal necrosis: Clinical manifestation and long-term visual outcomes in a series of polymerase chain reaction-positive patients.
Hedayatfar, Alireza; Ebrahimiadib, Nazanin; Zarei, Mohammad; Ashraf Khorasani, Maryam; Mahbod, Mirgholamreza; Asgari, Soheila; Sedaghat, Ahad.
Afiliación
  • Hedayatfar A; Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
  • Ebrahimiadib N; Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran.
  • Zarei M; Retina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Ashraf Khorasani M; Retina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Mahbod M; Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
  • Asgari S; Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran.
  • Sedaghat A; Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran.
Eur J Ophthalmol ; 31(4): 1961-1969, 2021 Jul.
Article en En | MEDLINE | ID: mdl-32567354
PURPOSE: To report the clinical spectrum, viral etiologies, therapeutic interventions, timing of rhegmatogenous retinal detachments (RRD), and visual outcomes in acute retinal necrosis (ARN) syndrome in a series of polymerase chain reaction (PCR)-positive eyes. METHODS: From January 2010 to January 2017, consecutive patients with the clinical diagnosis of ARN and a positive aqueous viral PCR were included in this observational, retrospective study. RESULTS: Nineteen eyes found to have a clinical diagnosis of ARN, of which 18 (94.7%) had a positive viral PCR. ARN was unilateral, except in one patient. None of the fellow eyes manifested ARN during follow-up. Varicella-zoster virus (VZV) was detected in 78.0% of ARN eyes. 61.1% of eyes experienced RRD. The median time for the occurrence of RRD was 12 weeks (range: 6-25 weeks) after disease onset. No correlation was found between the etiologic viral agent (VZV vs non-VZV; p = 1.000), extent of retinitis (1-2 quadrant vs 3-4 quadrants; p = 0.326), administration of intravitreal ganciclovir (injected vs not injected; p = 0.332), application of prophylactic laser retinopexy (applied vs not applied; p = 0.326), and subsequent occurrence of RRD.At a 2-year follow-up, visual impairment (VA ⩽ 20/200) and severe visual loss (VA ⩽ light perception) were significantly higher in those complicated by RRD compared to non-RRD eyes (81.8% vs 28.6%; p = 0.047, and 45.4% vs 0.0%; p = 0.004, respectively). CONCLUSION: Aqueous PCR results are highly consistent with the clinical diagnosis of ARN. Regardless of the method of management, the rate of RRD is high and is associated with a poor visual outcome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desprendimiento de Retina / Síndrome de Necrosis Retiniana Aguda Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Eur J Ophthalmol Asunto de la revista: OFTALMOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desprendimiento de Retina / Síndrome de Necrosis Retiniana Aguda Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Eur J Ophthalmol Asunto de la revista: OFTALMOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos