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Association between atopic keratoconjunctivitis and the risk of keratoconus.
Weng, Shih-Feng; Jan, Ren-Long; Wang, Jhi-Joung; Tseng, Sung-Huei; Chang, Yuh-Shin.
Afiliación
  • Weng SF; Department of Healthcare Administration and Medical Informatics, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Jan RL; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
  • Wang JJ; Center for Medical informatics and Statistics, Office of R&D, Kaohsiung Medical University, Kaohsiung, Taiwan.
  • Tseng SH; Department of Pediatrics, Chi Mei Medical Center, Liouying, Tainan, Taiwan.
  • Chang YS; Graduate Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan, Taiwan.
Acta Ophthalmol ; 99(1): e54-e61, 2021 Feb.
Article en En | MEDLINE | ID: mdl-32567209
PURPOSE: To investigate the risk of keratoconus (KCN) in patients with atopic keratoconjunctivitis (AKC). METHODS: This nationwide, retrospective, matched cohort study included 186 202 newly diagnosed AKC patients who were identified by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM), code 372.05, and selected from the Taiwan National Health Insurance Research Database. The age- and sex-matched control group included 186 202 non-AKC patients selected from the Taiwan Longitudinal Health Insurance Database 2000. Patient information was collected between 1 January 2004 and 31 December 2011, and both groups of patients were tracked from the index date until December 2013. The incidence and risk of KCN (ICD-9-CM, code 371.6) were compared between the groups. A Cox proportional hazard regression analysis was performed to obtain the adjusted hazard ratio (HR) for KCN. The cumulative KCN incidence rate was calculated with the Kaplan-Meier analysis. RESULTS: In total, 62 AKC patients and 26 controls developed KCN during the follow-up period. The incidence rate of KCN was 2.49 times (95% confidence interval [CI] = 1.57-3.93; p < 0.0001) higher in AKC patients than in controls. After adjusting for potential confounders, AKC patients were 2.25 times more likely to develop KCN than controls (adjusted HR, 2.25; 95% CI = 1.41-3.58; p < 0.05). CONCLUSION: Atopic keratoconjunctivitis (AKC) patients had an increased risk of developing KCN. Therefore, AKC patients should be advised of this risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medición de Riesgo / Queratoconjuntivitis / Queratocono Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Acta Ophthalmol Asunto de la revista: OFTALMOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medición de Riesgo / Queratoconjuntivitis / Queratocono Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Acta Ophthalmol Asunto de la revista: OFTALMOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Reino Unido