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Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis.
van Rossem, Lenie; Smit, Henriette A; Armand, Martine; Bernard, Jonathan Y; Bisgaard, Hans; Bønnelykke, Klaus; Bruun, Signe; Heude, Barbara; Husby, Steffen; Kyhl, Henriette B; Michaelsen, Kim F; Stark, Ken D; Thijs, Carel; Vinding, Rebecca K; Wijga, Alet H; Lauritzen, Lotte.
Afiliación
  • van Rossem L; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 GA, Utrecht, The Netherlands. l.vanrossem@umcutrecht.nl.
  • Smit HA; Department of Obstetrics and Gynaecology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. l.vanrossem@umcutrecht.nl.
  • Armand M; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584 GA, Utrecht, The Netherlands.
  • Bernard JY; Aix Marseille Univ, CNRS, CRMBM, Marseille, France.
  • Bisgaard H; Université de Paris, Centre for Research in Epidemiology and StatisticS (CRESS), INSERM, INRA, 75004, Paris, France.
  • Bønnelykke K; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
  • Bruun S; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
  • Heude B; Strategic Business Unit Pediatric, Arla Foods Ingredients Group P/S, Viby J, Denmark.
  • Husby S; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
  • Kyhl HB; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
  • Michaelsen KF; OPEN, Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark.
  • Stark KD; Université de Paris, Centre for Research in Epidemiology and StatisticS (CRESS), INSERM, INRA, 75004, Paris, France.
  • Thijs C; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
  • Vinding RK; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
  • Wijga AH; OPEN, Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark.
  • Lauritzen L; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
Eur J Nutr ; 60(2): 989-998, 2021 Mar.
Article en En | MEDLINE | ID: mdl-32564149
PURPOSE: It is controversial whether a higher intake of n-3 long-chain polyunsaturated fatty acids (n-3 LC PUFA) through breastfeeding is associated or not to a lower blood pressure (BP) during childhood. We aimed to clarify this point by undertaking a meta-analysis involving the data from seven European birth cohorts. METHODS: We searched https://www.birthcohort.net for studies that had collected breast milk samples, and had at least one BP measurement in childhood. Principal investigators were contacted, and all agreed to share data. One additional study was identified by contacts with the principal investigators. For each cohort, we analyzed the association of breast milk n-3 LC PUFAs with systolic and diastolic BP with linear mixed effects models or linear regression, and pooled the estimates with a random effects model. We also investigated age-specific and sex-specific associations. RESULTS: A total of 2188 participants from 7 cohorts were included. Overall, no associations between breast milk n-3 LC PUFAs and BP were observed. In the pooled analysis, each 0.1 wt% increment in breast milk docosahexaenoic acid (DHA) was associated with a 1.19 (95% CI - 3.31, 0.94) mmHg lower systolic BP. Associations were similar for boys and girls and at different ages. CONCLUSION: In this individual participant meta-analysis, we found no evidence for an association between breast milk n-3 LC PUFAs and BP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Grasos Omega-3 / Leche Humana Tipo de estudio: Systematic_reviews Límite: Female / Humans / Male Idioma: En Revista: Eur J Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Grasos Omega-3 / Leche Humana Tipo de estudio: Systematic_reviews Límite: Female / Humans / Male Idioma: En Revista: Eur J Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania