Your browser doesn't support javascript.
loading
Impact of Phenol-Enriched Virgin Olive Oils on the Postprandial Levels of Circulating microRNAs Related to Cardiovascular Disease.
Daimiel, Lidia; Micó, Víctor; Valls, Rosa M; Pedret, Anna; Motilva, María José; Rubió, Laura; Fitó, Montse; Farrás, Marta; Covas, María Isabel; Solá, Rosa; Ordovás, José M.
Afiliación
  • Daimiel L; Nutritional Control of the Epigenome Group, Instituto Madrileño de Estudios, Avanzados (IMDEA) Food Institute, CEI UAM+CSIC, Madrid, 28049, Spain.
  • Micó V; Nutritional Control of the Epigenome Group, Instituto Madrileño de Estudios, Avanzados (IMDEA) Food Institute, CEI UAM+CSIC, Madrid, 28049, Spain.
  • Valls RM; Functional Nutrition, Oxidation and Cardiovascular Disease Research Group, Universitat Rovira i Virgili, Hospital Universitari Sant Joan, EURECAT, Reus, 43204, Spain.
  • Pedret A; Functional Nutrition, Oxidation and Cardiovascular Disease Research Group, Universitat Rovira i Virgili, Hospital Universitari Sant Joan, EURECAT, Reus, 43204, Spain.
  • Motilva MJ; Food Technology Department, Agrotecnio Center, Escola Tècnica Superior d'Enginyeria Agrària, University of Lleida, Lleida, 25198, Spain.
  • Rubió L; Instituto de Ciencias de la Vid y del Vino-ICVV, (CSIC-Consejo Superior de Investigaciones Científicas, Universidad de La Rioja, Gobierno de La Rioja), Finca La Grajera, Ctra. de Burgos Km. 6 (LO-20 - salida 13), Logroño, La Rioja, 26007, Spain.
  • Fitó M; Cardiovascular Risk and Nutrition (Regicor Study Group), Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain. CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, 28029, Spain.
  • Farrás M; Cardiovascular Risk and Nutrition (Regicor Study Group), Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain. CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, 28029, Spain.
  • Covas MI; Cardiovascular Risk and Nutrition (Regicor Study Group), Hospital del Mar Medical Research Institute (IMIM), 08003 Barcelona, Spain. CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, 28029, Spain.
  • Solá R; Functional Nutrition, Oxidation and Cardiovascular Disease Research Group, Universitat Rovira i Virgili, Hospital Universitari Sant Joan, EURECAT, Reus, 43204, Spain.
  • Ordovás JM; Nutritional Genomics and Epigenomics Group, Instituto Madrileño de Estudios Avanzados (IMDEA) Food Institute, CEI UAM+CSIC, Madrid, 28049, Spain.
Mol Nutr Food Res ; 64(15): e2000049, 2020 08.
Article en En | MEDLINE | ID: mdl-32562310
SCOPE: We investigate the postprandial modulation of cardiovascular-related microRNAs elicited by extra virgin olive oil (EVOOs) containing different levels of their own polyphenols. METHODS AND RESULTS: It is randomized, postprandial, parallel, double-blind study. Twelve healthy participants consumed 30 mL of EVOO containing low (L-EVOO; 250 mg total phenols kg-1 of oil), medium (M-EVOO; 500 mg total phenols kg-1 of oil), and high (H-EVOO; 750 mg total phenols kg-1 of oil) enriched EVOOs. Postprandial plasma microRNAs levels are analyzed by real-time quantitative PCR. The results show that L-EVOO intake is associated with decreased let-7e-5p and miR-328a-3p levels and increased miR-17-5p and miR-20a-5p, concentrations. M-EVOO decreases plasma let-7e-5p and increases miR-17-5p, miR-20a-5p, and miR-192-5p levels. Finally, H-EVOO decreases let-7e-5p, miR-10a-5p, miR-21-5p, and miR-26b-5p levels. CONCLUSION: During the postprandial state, the levels of let-7e-5p decrease with EVOO regardless of polyphenol content suggesting a general response to the fatty acid composition of EVOO or/and the presence of at least 250 mg polyphenol kg-1 olive oil. Moreover, the miR-17-92 cluster increases by low and medium polyphenol content suggesting a role in fatty acid metabolism and nutrient sensing. Thus, postprandial modulation of circulating microRNAs levels could be a potential mechanism for the cardiovascular benefits associated with EVOO intake.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Enfermedades Cardiovasculares / MicroARNs / Aceite de Oliva / Ácidos Nucleicos Libres de Células Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Nutr Food Res Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Enfermedades Cardiovasculares / MicroARNs / Aceite de Oliva / Ácidos Nucleicos Libres de Células Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Nutr Food Res Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Alemania