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Classics in Neuroimaging: Imaging the Endocannabinoid Pathway with PET.
Varlow, Cassis; Boileau, Isabelle; Wey, Hsiao-Ying; Liang, Steven H; Vasdev, Neil.
Afiliación
  • Varlow C; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario M5T-1R8, Canada.
  • Boileau I; Institute of Medical Science, University of Toronto, Toronto, Ontario M5S-1A8, Canada.
  • Wey HY; Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario M5T-1R8, Canada.
  • Liang SH; Institute of Medical Science, University of Toronto, Toronto, Ontario M5S-1A8, Canada.
  • Vasdev N; Department of Psychiatry, University of Toronto, Toronto, Ontario M5T-1R8, Canada.
ACS Chem Neurosci ; 11(13): 1855-1862, 2020 07 01.
Article en En | MEDLINE | ID: mdl-32559067
This Viewpoint aims to highlight positron emission tomography (PET) research studies that have shaped our understanding of the endocannabinoid system (ECS) through radiopharmaceutical targeting of cannabinoid receptors 1 and 2 (CB1 and CB2), and the enzyme fatty acid amide hydrolase (FAAH), in several brain health illnesses including addiction, schizophrenia, eating disorders, and post-traumatic stress disorder. Advances in radiochemistry, including 11C-carbonylation and radiofluorination of nonactivated aromatic rings, are accelerating the translation of radiotracers with optimal kinetics, bringing us closer to clinical PET research studies to image the enzyme monoacylglycerol lipase (MAGL) and enabling the imaging of unexplored targets in the ECS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endocannabinoides / Monoacilglicerol Lipasas Idioma: En Revista: ACS Chem Neurosci Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endocannabinoides / Monoacilglicerol Lipasas Idioma: En Revista: ACS Chem Neurosci Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos