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Prospective longitudinal evaluation of cytokines in mild cognitive impairment due to AD and Lewy body disease.
Thomas, Alan J; Hamilton, Calum A; Donaghy, Paul C; Martin-Ruiz, Carmen; Morris, Chris M; Barnett, Nicola; Olsen, Kirsty; Taylor, John-Paul; O'Brien, John T.
Afiliación
  • Thomas AJ; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
  • Hamilton CA; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
  • Donaghy PC; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
  • Martin-Ruiz C; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
  • Morris CM; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
  • Barnett N; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
  • Olsen K; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
  • Taylor JP; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
  • O'Brien JT; Department of Psychiatry, University of Cambridge, Cambridge, UK.
Int J Geriatr Psychiatry ; 35(10): 1250-1259, 2020 10.
Article en En | MEDLINE | ID: mdl-32557792
OBJECTIVES: We conducted a prospective longitudinal study of plasma cytokines during the Mild Cognitive Impairment (MCI) stage of Lewy body disease and Alzheimer's disease, hypothesizing that cytokine levels would decrease over time and that this would be correlated with decline in cognition. METHODS: Older (≥60) people with MCI were recruited from memory services in healthcare trusts in North East England, UK. MCI was diagnosed as due to Alzheimer's disease (MCI-AD) or Lewy body disease (MCI-LB). Baseline and repeat annual clinical and cognitive assessments were undertaken and plasma samples were obtained at the same time. Cytokine assays were performed on all samples using the Meso Scale Discovery V-Plex Plus Proinflammatory Panel 1, which included IFNγ, IL-1ß, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13 and TNFα. RESULTS: Fifty-six patients (21 MCI-AD, 35 MCI-LB) completed prospective evaluations and provided samples up to 3 years after baseline. Six cytokines (IFNγ, IL-1ß, IL-2, IL-4, IL-6 and IL-10) showed highly significant (P < .002) decreases over time. AD and LB did not differ in rate of decrease nor were there any effects related to age or general morbidity. Decrease in five of these cytokines (IFNγ, IL-1ß, IL-2, IL-4, and IL-10) was highly correlated with decrease in cognition (P < .003). CONCLUSIONS: Peripheral inflammation decreased in both disease groups during MCI suggesting this may be a therapeutic window for future anti-inflammatory agents.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad por Cuerpos de Lewy / Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Observational_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Int J Geriatr Psychiatry Asunto de la revista: GERIATRIA / PSIQUIATRIA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad por Cuerpos de Lewy / Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Observational_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Int J Geriatr Psychiatry Asunto de la revista: GERIATRIA / PSIQUIATRIA Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido