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Bacterial spectrum and antibiotic resistance of urinary tract infections in patients treated for upper urinary tract calculi: a multicenter analysis.
De Lorenzis, Elisa; Alba, Alberto Budia; Cepeda, Marcos; Galan, Juan Antonio; Geavlete, Petrisor; Giannakopoulos, Stilianos; Saltirov, Iliya; Sarica, Kemal; Skolarikos, Andreas; Stavridis, Sotir; Yuruk, Emrah; Geavlete, Bogdan; Hristoforov, Stefan; Karagoz, M Ali; Nassos, Nikolaos; Jurado, Guzmán Ordaz; Paslanmaz, Filip; Poza, Marina; Saidi, Skender; Tzelves, Lazaros; Trinchieri, Alberto.
Afiliación
  • De Lorenzis E; Dept. of Urology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via della Commenda 15, 20122, Milan, Italy. elisa.delorenzis@gmail.com.
  • Alba AB; Department of Clinical Sciences and Community Health, University of Milan, Via della Commenda 15, 20122, Milan, Italy. elisa.delorenzis@gmail.com.
  • Cepeda M; Lithotripsy and Endourology Unit, La Fe University and Polytechnic Hospital, Valencia, Spain.
  • Galan JA; Urology Unit, Hospital Universitario Río Hortega, Valladolid, Spain.
  • Geavlete P; Urolithiasis and Endourology Unit, General University Hospital, Alicante, Spain.
  • Giannakopoulos S; Saint John Emergency Clinical Hospital, Bucharest, Romania.
  • Saltirov I; Department of Urology, Democritus University of Thrace, Dragana, Alexandroupolis, Greece.
  • Sarica K; Department of Urology and Nephrology, Military Medical Academy, Sofia, Bulgaria.
  • Skolarikos A; Department of Urology, Biruni University, Medical School, Istanbul, Turkey.
  • Stavridis S; 2nd Department of Urology, University of Athens, Sismanoglio Hospital, Athens, Greece.
  • Yuruk E; University Clinic of Urology, Medical Faculty Skopje, Skopje, North Macedonia.
  • Geavlete B; Department of Urology, The Ministry of Health, University of Health Sciences, Bagcilar Training & Research Hospital, Istanbul, Turkey.
  • García-Carbajosa; Saint John Emergency Clinical Hospital, Bucharest, Romania.
  • Hristoforov S; Urolithiasis and Endourology Unit, General University Hospital, Alicante, Spain.
  • Karagoz MA; Department of Urology and Nephrology, Military Medical Academy, Sofia, Bulgaria.
  • Nassos N; Department of Urology, Kafkas University Medical School, Kars, Turkey.
  • Jurado GO; Department of Urology, Democritus University of Thrace, Dragana, Alexandroupolis, Greece.
  • Paslanmaz F; Lithotripsy and Endourology Unit, La Fe University and Polytechnic Hospital, Valencia, Spain.
  • Poza M; Department of Urology, The Ministry of Health, University of Health Sciences, Bagcilar Training & Research Hospital, Istanbul, Turkey.
  • Saidi S; Urology Unit, Hospital Universitario Río Hortega, Valladolid, Spain.
  • Tzelves L; University Clinic of Urology, Medical Faculty Skopje, Skopje, North Macedonia.
  • Trinchieri A; 2nd Department of Urology, University of Athens, Sismanoglio Hospital, Athens, Greece.
Eur J Clin Microbiol Infect Dis ; 39(10): 1971-1981, 2020 Oct.
Article en En | MEDLINE | ID: mdl-32557326
The purpose of this study is to collect information on the bacterial resistance to antibiotics of bacteria isolated from urine cultures of patients treated for upper urinary tract calculi. Data of patients with urinary tract infection and urolithiasis were retrospectively reviewed to collect information on age, gender, stone size, location, hydronephrosis, procedure of stone removal and antibiotic treatment, identification and susceptibility of pathogens, symptoms, and infectious complications. A total of 912 patients from 11 centers in 7 countries (Bulgaria, Greece, Italy, North Macedonia, Spain, and Turkey) were studied. Mean age was 54 ± 16 years and M/F ratio 322/590. Out of 946 microbial isolates, the most common were E. coli, Gram-positive, KES group (Klebsiella, Enterobacter, Serratia), Proteus spp., and P. aeruginosa. Carbapenems, piperacillin/tazobactam and amikacin showed low resistance rates to E. coli (2.5%, 7%, and 3.6%) and Proteus spp. (7.7%, 16%, and 7.4%), but higher rates were observed with Klebsiella spp., P. aeruginosa, and Gram-positive. Fosfomycin had resistance rates less than 10% to E. coli, 23% to KES group, and 19% to Gram-positive. Amoxicillin/clavulanate, cephalosporins, quinolones, and TMP/SMX showed high resistance rates to most bacterial strains. High rates of antibiotic resistance were observed in patients candidate to stone treatment from South-Eastern Europe. The empirical use of antibiotics with low resistance rates should be reserved to the most serious cases to avoid the increase of multidrug resistant bacteria. Basing on our results, carbapenems, piperacillin/tazobactam, and amikacin may be a possible option for empiric treatment of urinary stone patients showing systemic symptoms.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Infecciones Bacterianas / Infecciones Urinarias / Urolitiasis / Antiinfecciosos Tipo de estudio: Observational_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Eur J Clin Microbiol Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Infecciones Bacterianas / Infecciones Urinarias / Urolitiasis / Antiinfecciosos Tipo de estudio: Observational_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Eur J Clin Microbiol Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania