Your browser doesn't support javascript.
loading
Zataria multiflora Boiss. Essential Oil Induce Apoptosis in Two Human Colon Cancer Cell Lines (HCT116 & SW48).
Ahani, Narges; Sangtarash, Mohammad Hossein; Alipour Eskandani, Majid; Houshmand, Massoud.
Afiliación
  • Ahani N; Department of Biology, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran.
  • Sangtarash MH; Department of Biology, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran.
  • Alipour Eskandani M; Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran.
  • Houshmand M; Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Iran J Public Health ; 49(4): 753-762, 2020 Apr.
Article en En | MEDLINE | ID: mdl-32548056
BACKGROUND: Zataria multiflora Boiss. is known by the common Persian name "Avishan-e-Shirazi", is one of the best-known medicinal herbs belonging to the Labiatae (Lamiaceae) family. The aim of this study was to evaluate the anticancer effects and the underlying mechanisms of how Z. multiflora Boiss., essential oil induced apoptosis in the human colorectal tumor cell lines (HCT116 & SW48). METHODS: This study was conducted in National Institute of Genetic Engineering and Biotechnology (NIGEB) (Tehran, Iran) from 2017 to 2019. The cytotoxicity of this essential oil was assessed by 3- (4,5-di-methylthiazol-2-yl)- 2,5-diphenyltetra-zolium bromide (MTT) assay, trypan blue exclusion, and colony formation assays. We assessed apoptosis and measure intracellular reactive oxygen species (ROS) by flow cytometry. Then gene expression was analyzed by Quantitative Real-Time RT-PCR. RESULTS: Z. multiflora Boiss., essential oil time- and dose-dependently inhibits cell proliferation and also induced apoptosis in both cell lines via UCP2-related mitochondrial pathway by the induction of intracellular ROS. CONCLUSION: Z. multiflora Boiss., essential oil could be a good candidate for use as an inhibitor of the growth of colorectal tumor cells.
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Iran J Public Health Año: 2020 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Irán

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Iran J Public Health Año: 2020 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Irán