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Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine.
Koklesova, Lenka; Liskova, Alena; Samec, Marek; Qaradakhi, Tawar; Zulli, Anthony; Smejkal, Karel; Kajo, Karol; Jakubikova, Jana; Behzadi, Payam; Pec, Martin; Zubor, Pavol; Biringer, Kamil; Kwon, Taeg Kyu; Büsselberg, Dietrich; Sarria, Gustavo R; Giordano, Frank A; Golubnitschaja, Olga; Kubatka, Peter.
Afiliación
  • Koklesova L; Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.
  • Liskova A; Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.
  • Samec M; Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.
  • Qaradakhi T; Institute for Health and Sport, Victoria University, Melbourne, VIC Australia.
  • Zulli A; Institute for Health and Sport, Victoria University, Melbourne, VIC Australia.
  • Smejkal K; Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, 612 42 Brno, Czech Republic.
  • Kajo K; Department of Pathology, St. Elisabeth Oncology Institute, 812 50 Bratislava, Slovakia.
  • Jakubikova J; Biomedical Research Center, Slovak Academy of Sciences, 845 05 Bratislava, Slovakia.
  • Behzadi P; Biomedical Research Center SAS, Cancer Research Institute, Bratislava, Slovakia.
  • Pec M; Department of Microbiology, College of Basic Sciences, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran.
  • Zubor P; Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.
  • Biringer K; Department of Gynecologic Oncology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
  • Kwon TK; OBGY Health & Care, Ltd., 01001 Zilina, Slovakia.
  • Büsselberg D; Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.
  • Sarria GR; Department of Immunology and School of Medicine, Keimyung University, Dalseo-Gu, Daegu, 42601 Korea.
  • Giordano FA; Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, P.O. Box 24144, Doha, Qatar.
  • Golubnitschaja O; Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.
  • Kubatka P; Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.
EPMA J ; 11(2): 261-287, 2020 Jun.
Article en En | MEDLINE | ID: mdl-32547652
Severe durable changes may occur to the DNA structure caused by exogenous and endogenous risk factors initiating the process of carcinogenesis. By evidence, a large portion of malignancies have been demonstrated as being preventable. Moreover, the targeted prevention of cancer onset is possible, due to unique properties of plant bioactive compounds. Although genoprotective effects of phytochemicals have been well documented, there is an evident lack of articles which would systematically present the spectrum of anticancer effects by phytochemicals, plant extracts, and plant-derived diet applicable to stratified patient groups at the level of targeted primary (cancer development) and secondary (cancer progression and metastatic disease) prevention. Consequently, clinical implementation of knowledge accumulated in the area is still highly restricted. To stimulate coherent co-development of the dedicated plant bioactive compound investigation on one hand and comprehensive cancer preventive strategies on the other hand, the current paper highlights and deeply analyses relevant evidence available in the area. Key molecular mechanisms are presented to detail genoprotective and anticancer activities of plants and phytochemicals. Clinical implementation is discussed. Based on the presented evidence, advanced chemopreventive strategies in the context of 3P medicine are considered.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: EPMA J Año: 2020 Tipo del documento: Article País de afiliación: Eslovaquia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: EPMA J Año: 2020 Tipo del documento: Article País de afiliación: Eslovaquia Pais de publicación: Suiza