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Serum Hepcidin Levels in Cognitively Normal Older Adults with High Neocortical Amyloid-ß Load.
Chatterjee, Pratishtha; Mohammadi, Maryam; Goozee, Kathryn; Shah, Tejal M; Sohrabi, Hamid R; Dias, Cintia B; Shen, Kaikai; Asih, Prita R; Dave, Preeti; Pedrini, Steve; Ashton, Nicholas J; Hye, Abdul; Taddei, Kevin; Lovejoy, David B; Zetterberg, Henrik; Blennow, Kaj; Martins, Ralph N.
Afiliación
  • Chatterjee P; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.
  • Mohammadi M; School of Medical Health and Sciences, Edith Cowan University, Joondalup, WA, Australia.
  • Goozee K; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.
  • Shah TM; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.
  • Sohrabi HR; School of Medical Health and Sciences, Edith Cowan University, Joondalup, WA, Australia.
  • Dias CB; KaRa Institute of Neurological Disease, Sydney, Macquarie Park, NSW, Australia.
  • Shen K; Anglicare, Sydney, Castle Hill, NSW, Australia.
  • Asih PR; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA, Australia.
  • Dave P; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.
  • Pedrini S; School of Medical Health and Sciences, Edith Cowan University, Joondalup, WA, Australia.
  • Ashton NJ; Australian Alzheimer's Research Foundation, Nedlands, WA, Australia.
  • Hye A; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.
  • Taddei K; School of Medical Health and Sciences, Edith Cowan University, Joondalup, WA, Australia.
  • Lovejoy DB; School of Psychiatry and Clinical Neurosciences, University of Western Australia, Crawley, WA, Australia.
  • Zetterberg H; Australian Alzheimer's Research Foundation, Nedlands, WA, Australia.
  • Blennow K; Centre for Healthy Ageing, School of Psychology and Exercise Science, Murdoch University, South Street, Murdoch, WA, Australia.
  • Martins RN; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.
J Alzheimers Dis ; 76(1): 291-301, 2020.
Article en En | MEDLINE | ID: mdl-32538848
BACKGROUND/OBJECTIVE: Hepcidin, an iron-regulating hormone, suppresses the release of iron by binding to the iron exporter protein, ferroportin, resulting in intracellular iron accumulation. Given that iron dyshomeostasis has been observed in Alzheimer's disease (AD) together with elevated serum hepcidin levels, the current study examined whether elevated serum hepcidin levels are an early event in AD pathogenesis by measuring the hormone in cognitively normal older adults at risk of AD, based on high neocortical amyloid-ß load (NAL). METHODS: Serum hepcidin levels in cognitively normal participants (n = 100) aged between 65-90 years were measured using ELISA. To evaluate NAL, all participants underwent 18F-florbetaben positron emission tomography. A standard uptake value ratio (SUVR)<1.35 was classified as low NAL (n = 65) and ≥1.35 (n = 35) was classified as high NAL. RESULTS: Serum hepcidin was significantly higher in participants with high NAL compared to those with low NAL before and after adjusting for covariates: age, gender, and APOEɛ4 carriage (p < 0.05). A receiver operating characteristic curve based on a logistic regression of the same covariates, the base model, distinguished high from low NAL (area under the curve, AUC = 0.766), but was outperformed when serum hepcidin was added to the base model (AUC = 0.794) and further improved with plasma Aß42/40 ratio (AUC = 0.829). CONCLUSION: The present findings indicate that serum hepcidin is increased in individuals at risk for AD and contribute to the body of evidence supporting iron dyshomeostasis as an early event of AD. Further, hepcidin may add value to a panel of markers that contribute toward identifying individuals at risk of AD; however, further validation studies are required.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Péptidos beta-Amiloides / Cognición / Neocórtex / Hepcidinas Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Péptidos beta-Amiloides / Cognición / Neocórtex / Hepcidinas Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: J Alzheimers Dis Asunto de la revista: GERIATRIA / NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos