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[Expression and clinical significance of LRFN4 in colorectal cancer tissue].
Zheng, F; Zhai, X L; Wang, W J; Guo, K P; Xiao, C C; Ni, Q C.
Afiliación
  • Zheng F; Department of General Surgery, Shanghai Electric Power Hospital, Shanghai, 200050, China.
  • Zhai XL; Department of Oncology, the Second Affiliated Hospital of Nantong University, Nantong 226001, China.
  • Wang WJ; Department of General Surgery, Shanghai Electric Power Hospital, Shanghai, 200050, China.
  • Guo KP; Department of General Surgery, Shanghai Electric Power Hospital, Shanghai, 200050, China.
  • Xiao CC; Department of General Surgery, Shanghai Electric Power Hospital, Shanghai, 200050, China.
  • Ni QC; Department of General Surgery, Nantong University Affiliated Hospital, Nantong 226001, China.
Zhonghua Yi Xue Za Zhi ; 100(22): 1745-1749, 2020 Jun 09.
Article en Zh | MEDLINE | ID: mdl-32536098
Objective: To investigate the expression and clinical significance of LRFN4 in colorectal cancer. Methods: A total of 210 cases of colorectal cancer tissues and 228 cases of corresponding surgical margin tissues were collected. Immunohistochemistry was employed to evaluate the expression of LRFN4 in colorectal cancer.The correlation between LRFN4 expression and clinicopathological features of colorectal cancer as well as patient outcome were analyzed. Results: The positive rate of LRFN4 in colorectal cancer and in non-cancer was 55.24%(116/210), and 37.28% (85/228) , respectively.The expression of LRFN4 in colorectal cancer tissues was higher than that in non-cancer tissues(χ(2)=14.196, P<0.001). High expression of LRFN4 was significantly correlated with tumor location(χ(2)=4.133,P=0.042), T staging(χ(2)=6.494,P=0.039), N staging(χ(2)=11.715,P=0.008), TNM staging(χ(2)=13.398,P=0.004), CEA (χ(2)=6.017, P=0.049), but without gender, age, degree of differentiation, M staging(P>0.05).The Kaplan-Meier survival curves indicated that high LRFN4 expression was associated with good survival (P<0.05). In addition, Cox proportional hazards model showed that the high expression of LRFN4(HR=0.585, P=0.018)was an independent risk factor for prognosis in patients with colorectal cancer. Conclusions: The expression of LRFN4 is up-regulated in colorectal cancer, which is significantly correlated with the clinicopathological features and prognosis. High expression of LRFN4 reduced the risk of death in patients with colorectal cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: Zh Revista: Zhonghua Yi Xue Za Zhi Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: Zh Revista: Zhonghua Yi Xue Za Zhi Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: China