Recent advances and prospects in nano drug delivery systems using lipopolyoxazolines.
Int J Pharm
; 585: 119536, 2020 Jul 30.
Article
en En
| MEDLINE
| ID: mdl-32531447
Facing the growing demand in nano drug delivery systems (nDDS), hybrid excipients based on natural molecules and well-defined synthetic polymers are intensively investigated. Lipopolyoxazolines (LipoPOx) composed of a polyoxazoline block (POx) and a lipid or lipid-like derivative are detailed in this review. The nature of lipids used, the route to synthesize LipoPOx and their advantages for the formulation of drugs are reported. The place of POx family in nanomedicine is discussed compared to PEG, considered as the gold standard of hydrophilic polymers. LipoPOx nanoformulations including liposomes, mixed micelles, lipid nanocapsules are provided alongside discussion of the nDDS for intravenous or topical administration.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxazoles
/
Polietilenglicoles
/
Sistemas de Liberación de Medicamentos
/
Nanopartículas
/
Lípidos
Límite:
Humans
Idioma:
En
Revista:
Int J Pharm
Año:
2020
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Países Bajos