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Bioaccumulation of ytterbium oxide nanoparticles insinuate oxidative stress, inflammatory, and pathological lesions in ICR mice.
Adeel, Muhammad; Tingting, Jin; Hussain, Tariq; He, Xiao; Ahmad, Muhammad Arslan; Irshad, Muhammad Kashif; Shakoor, Noman; Zhang, Peng; Changjian, Xie; Hao, Yi; Zhiyong, Zhang; Javed, Rabia; Rui, Yukui.
Afiliación
  • Adeel M; Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Sciences, China Agricultural University, Beijing, 100193, China.
  • Tingting J; Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Sciences, China Agricultural University, Beijing, 100193, China.
  • Hussain T; Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory, College of Veterinary Medicine, China Agricultural University, Beijing, China.
  • He X; Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
  • Ahmad MA; Key Lab of Eco-restoration of Regional Contaminated Environment, Ministry of Education, Shenyang University, Shenyang, 110044, People's Republic of China.
  • Irshad MK; Department of Tissue Engineering, China Medical University, Shenyang, 110122, People's Republic of China.
  • Shakoor N; Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Sciences, China Agricultural University, Beijing, 100193, China.
  • Zhang P; Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Sciences, China Agricultural University, Beijing, 100193, China.
  • Changjian X; School of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham, UK.
  • Hao Y; Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
  • Zhiyong Z; Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation, College of Resources and Environmental Sciences, China Agricultural University, Beijing, 100193, China.
  • Javed R; Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
  • Rui Y; Department of Tissue Engineering, China Medical University, Shenyang, 110122, People's Republic of China.
Environ Sci Pollut Res Int ; 27(26): 32944-32953, 2020 Sep.
Article en En | MEDLINE | ID: mdl-32524406
With the rapid development in nanoscience and nanotechnology, rare earth oxide nanomaterials (REO-NMs) have been increasingly used due to their unique physical and chemical characteristics. Despite the increasing applications of REO NPs, scarce information is available on their detrimental effects. In the current study, we investigate the toxic effect of ytterbium oxide nanoparticles (Yb2O3 NPs) in mouse model by using various techniques including inductively coupled plasma mass spectrometry (ICP-MS) analysis over 30 days of exposure. Furthermore, we elucidated lung lavage fluid of mice for biochemical and cytological analysis, and lung tissues for histopathology to interpret the NP side effects. We observed a significant concentration of Yb2O3 NPs accumulated in the lung, liver, kidney, and heart tissues. Similarly, increased bioaccumulation of Yb content was found in the olfactory bulb compared to other reigns of brain. The cytological analysis of bronchoalveolar lavage fluid (BALF) revealed a significant elevation in the percentage of neutrophils and lymphocytes. Biochemical analysis showed an instilled Yb2O3 NPs, showing signs of oxidative damage through up-regulation of 60-87% of MDA while down-regulation of 20-40% of GSH-PX and GSH content. The toxicity pattern was more evident from histopathological observations. These interpretations provide enough evidence of bioaccumulation of Yb2O3 NPs in mice tissues. Overall, our findings reveal that acute exposure of Yb2O3 NPs through intranasal inhalation may cause toxicity via oxidative stress, which leads to a chronic inflammatory response. Graphical abstract Graphical illustrations of experimental findings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas / Nanopartículas del Metal Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Environ Sci Pollut Res Int Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas / Nanopartículas del Metal Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Environ Sci Pollut Res Int Asunto de la revista: SAUDE AMBIENTAL / TOXICOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania