Octahedral Molybdenum Cluster Complexes with Optimized Properties for Photodynamic Applications.
Inorg Chem
; 59(13): 9287-9293, 2020 Jul 06.
Article
en En
| MEDLINE
| ID: mdl-32516524
Two new octahedral molybdenum cluster complexes act as an efficient singlet oxygen supplier in the context of the photodynamic therapy of cancer cells under blue-light irradiation. These complexes integrate the {Mo6I8}4+ core with 4'-carboxybenzo-15-crown-5 or cholate apical ligands and were characterized by 1H NMR, HR ESI-MS, and CHN elemental analysis. Both complexes display high quantum yields of luminescence and singlet oxygen formation in aqueous media associated with a suitable stability against hydrolysis. They are internalized into lysosomes of HeLa cells with no dark toxicity at pharmacologically relevant concentrations and have a strong phototoxic effect under blue-light irradiation, even in the presence of fetal bovine serum. The last feature is essential for further translation to in vivo experiments. Overall, these complexes are attractive molecular photosensitizers toward photodynamic applications.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fármacos Fotosensibilizantes
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Complejos de Coordinación
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Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Inorg Chem
Año:
2020
Tipo del documento:
Article
País de afiliación:
República Checa
Pais de publicación:
Estados Unidos