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The inhibition of IL-2/IL-2R gives rise to CD8+ T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia.
Shi, Hongbo; Wang, Wenjing; Yin, Jiming; Ouyang, Yabo; Pang, Lijun; Feng, Yingmei; Qiao, Luxin; Guo, Xianghua; Shi, Honglin; Jin, Ronghua; Chen, Dexi.
Afiliación
  • Shi H; Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, 100069, Beijing, China.
  • Wang W; Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer, Beijing, China.
  • Yin J; Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, 100069, Beijing, China.
  • Ouyang Y; Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer, Beijing, China.
  • Pang L; Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, 100069, Beijing, China.
  • Feng Y; Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer, Beijing, China.
  • Qiao L; Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, 100069, Beijing, China.
  • Guo X; Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer, Beijing, China.
  • Shi H; Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, 100069, Beijing, China.
  • Jin R; Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer, Beijing, China.
  • Chen D; Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, 100069, Beijing, China.
Cell Death Dis ; 11(6): 429, 2020 06 08.
Article en En | MEDLINE | ID: mdl-32513989
Although most patients with COVID-19 pneumonia have a good prognosis, some patients develop to severe or critical illness, and the mortality of critical cases is up to 61.5%. However, specific molecular information about immune response in critical patients with COVID-19 is poorly understood. A total of 54 patients were enrolled and divided into three groups, among which 34 were common, 14 were severe, and 6 were critical. The constitution of peripheral blood mononuclear cells (PBMC) in patients was analyzed by CyTOF. The profile of cytokines was examined in plasma of patients using luminex. The IL-2 signaling pathway was investigated in the PBMC of patients by qRT-PCR. The count and percentage of lymphocytes were significantly decreased in critical patients compared to common and severe patients with COVID-19 pneumonia. The count of T cells, B cells, and NK cells was remarkably decreased in critical patients compared to normal controls. The percentage of CD8+ T cells was significantly lower in critical patients than that in common and severe patients with COVID-19 pneumonia. The expression of IL-2R, JAK1, and STAT5 decreased in PBMC of common, severe, and critical patients, but IL-2 level was elevated in severe patients and decreased in critical patients with COVID-19 pneumonia. The decrease of CD8+ T cells in critical patients with COVID-19 pneumonia may be related to the IL-2 signaling pathway. The inhibition of IL-2/IL-2R gives rise to CD8+ T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Viral / Interleucina-2 / Infecciones por Coronavirus / Linfocitos T CD8-positivos / Proteínas Supresoras de Tumor / Factor de Transcripción STAT5 / Janus Quinasa 1 / Subunidad alfa del Receptor de Interleucina-2 / Betacoronavirus Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Death Dis Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía Viral / Interleucina-2 / Infecciones por Coronavirus / Linfocitos T CD8-positivos / Proteínas Supresoras de Tumor / Factor de Transcripción STAT5 / Janus Quinasa 1 / Subunidad alfa del Receptor de Interleucina-2 / Betacoronavirus Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Death Dis Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido