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Frequency of menstrual abnormalities and their associated neuroimaging findings in women with focal refractory epilepsy.
Ranjbar, Mahta; Mehvari Habibabadi, Jafar; Poorazarian, Farinaz; Mohammadi, Banafshe; Naghibi, Seyed Navid; Tabrizi, Nasim.
Afiliación
  • Ranjbar M; Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Mehvari Habibabadi J; Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Poorazarian F; Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Mohammadi B; Department of Obstetrics and Gynecology, Reasearch and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Naghibi SN; Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Kashani Hospital Epilepsy Center, Isfahan, Iran. Navidnaghibi.neuro@gmail.come.
  • Tabrizi N; Neurology Department, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Acta Neurol Belg ; 121(5): 1247-1250, 2021 Oct.
Article en En | MEDLINE | ID: mdl-32507941
Patients with refractory epilepsy can suffer from psychological and physical problems. Epilepsy can also be associated with menstruation abnormalities in women. In this paper, we aim to survey women with focal refractory epilepsy who also suffer from menstrual abnormalities. This cross-sectional study was performed in 2018 in Tertiary Epilepsy Center in Kashani Hospital, Isfahan, Iran and Milad hospital, Isfahan, Iran. A total number of 381 patients diagnosed with refractory epilepsy joined the study based on an inclusion and exclusion criteria. Clinical characteristics of epilepsy, menstrual issues and brain MRI findings were assessed. Among 381 women with refractory epilepsy, 250 had refractory focal epilepsy (65.61%), and the others (34.39%) had generalized refractory epilepsy. 132 patients out of 381 had menstrual abnormalities (34.65%). Among 132 women with coexisting refractory epilepsy and menstrual abnormalities, 86 (65.15%) were diagnosed with refractory focal epilepsy, and 46 (34.86%) had generalized refractory epilepsy (p value = 0.041). Oligomenorrhea-hypomenorrhea was the most common type of menstrual abnormality in women with refractory epilepsy seen in 83 (62.87%) (p value = 0.039). The most common brain MRI pathology in women with refractory focal epilepsy was mesial temporal sclerosis (MTS) (39.20%, p = 0.00). We report that almost one-third of women with refractory epilepsy suffer from menstrual disorders, and the most common disorder was Oligomenorrhea-hypomenorrhea, and the most common brain pathology was MTS. It has also been a hypothesis that reproductive dysfunctions are connected to temporal lobe malfunctions, and more specific studies are required in this issue.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Epilepsias Parciales / Epilepsia Refractaria / Trastornos de la Menstruación Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Middle aged Idioma: En Revista: Acta Neurol Belg Año: 2021 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Italia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Epilepsias Parciales / Epilepsia Refractaria / Trastornos de la Menstruación Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Middle aged Idioma: En Revista: Acta Neurol Belg Año: 2021 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Italia