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Do neurobiological differences exist between paranoid and non-paranoid schizophrenia? Findings from the bipolar schizophrenia network on intermediate phenotypes study.
Lutz, Olivia; Lizano, Paulo; Mothi, Suraj Sarvode; Zeng, Victor; Hegde, Rachal R; Hoang, Dung T; Henson, Philip; Brady, Roscoe; Tamminga, Carol A; Pearlson, Godfrey; Clementz, Brett A; Sweeney, John A; Keshavan, Matcheri S.
Afiliación
  • Lutz O; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United States of America.
  • Lizano P; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Department of Psychiatry, Harvard Medical School, Boston, MA, United States of America.
  • Mothi SS; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United States of America.
  • Zeng V; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United States of America.
  • Hegde RR; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United States of America.
  • Hoang DT; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United States of America.
  • Henson P; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United States of America.
  • Brady R; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Department of Psychiatry, Harvard Medical School, Boston, MA, United States of America.
  • Tamminga CA; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States of America.
  • Pearlson G; Department of Psychiatry, Yale University, New Haven, CT, United States of America.
  • Clementz BA; Department of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens, GA, United States of America.
  • Sweeney JA; Department of Psychiatry, University of Cincinnati, Cincinnati, OH, United States of America.
  • Keshavan MS; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Department of Psychiatry, Harvard Medical School, Boston, MA, United States of America. Electronic address: mkeshava@bidmc.harvard.edu.
Schizophr Res ; 223: 96-104, 2020 09.
Article en En | MEDLINE | ID: mdl-32507376
Subtypes of schizophrenia, constructed using clinical phenomenology to resolve illness heterogeneity, have faced criticism due to overlapping symptomatology and longitudinal instability; they were therefore dropped from the Diagnostic Statistical Manual-5. Cognitive and imaging findings comparing paranoid (P-SZ) and non-paranoid (disorganized, residual and undifferentiated; NP-SZ) schizophrenia have been limited due to small sample sizes. We assessed P-SZ and NP-SZ using symptomatology, cognition and brain structure and predicted that there would be few neurobiological differences. P-SZ (n = 237), NP-SZ (n = 127) and controls (n = 430) were included from a multi-site study. In a subset of this sample, structural imaging measures (P-SZ, n = 133; NP-SZ, n = 67; controls, n = 310) were calculated using Freesurfer 6.0. Group contrasts were run using analysis of covariance, controlling for age, sex, race and site, p-values were corrected using False Discovery Rate (FDR) and were repeated excluding the residual subtype. Compared to NP-SZ (with and without the residual subtype), P-SZ displayed fewer negative symptoms, faster speed of processing, larger bilateral hippocampus, right amygdala and their subfield volumes. Additionally, NP-SZ (with residual subtype) displayed fewer depressive symptoms and higher left transverse temporal cortical thickness (CT) but NP-SZ without residual subtype showed lower GAF scores and worse digit sequencing compared to P-SZ. No differences in positive symptoms and functioning (global or social) were detected. Subtle but significant differences were seen in cognition, symptoms, CT and subcortical volumes between P-SZ and NP-SZ. While the magnitude of these differences is not large enough to justify them as distinct categories, the paranoid- nonparanoid distinction in schizophrenia merits further investigation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Trastorno Bipolar Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies / Qualitative_research Límite: Humans Idioma: En Revista: Schizophr Res Asunto de la revista: PSIQUIATRIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Trastorno Bipolar Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies / Qualitative_research Límite: Humans Idioma: En Revista: Schizophr Res Asunto de la revista: PSIQUIATRIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos