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Cross-Sectional and Longitudinal Construct Validity of the Generic KINDL-A(dult)B(rief) Questionnaire in Adults with Thrombophilia or with Hereditary and Acquired Bleeding Disorders.
Neuner, Bruno; von Mackensen, Sylvia; Kiesau, Bettina; Krampe, Henning; McCarthy, William J; Reinke, Sarah; Kowalski, Dorothee; Shneyder, Maria; Clausnizer, Hartmut; Rocke, Angela; Junker, Ralf; Nowak-Göttl, Ulrike.
Afiliación
  • Neuner B; Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Campus Charité Mitte and Campus Virchow-Klinikum, Berlin, Germany.
  • von Mackensen S; Department of Medical Psychology, Center for Psychosocial Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
  • Kiesau B; Institute for Clinical Chemistry and Coagulation Center, University Hospital Schleswig Holstein, Lübeck/Kiel, Germany.
  • Krampe H; Department of Anesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Campus Charité Mitte and Campus Virchow-Klinikum, Berlin, Germany.
  • McCarthy WJ; Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Center for Cancer Prevention and Control Research, University of California Los Angeles (UCLA), Los Angeles, California, USA.
  • Reinke S; Institute for Clinical Chemistry and Coagulation Center, University Hospital Schleswig Holstein, Lübeck/Kiel, Germany.
  • Kowalski D; Department of Pediatric Oncology and Hematology, University Childrens' Hospital, Münster, Germany.
  • Shneyder M; Institute for Clinical Chemistry and Coagulation Center, University Hospital Schleswig Holstein, Lübeck/Kiel, Germany.
  • Clausnizer H; Institute for Clinical Chemistry and Coagulation Center, University Hospital Schleswig Holstein, Lübeck/Kiel, Germany.
  • Rocke A; Institute for Clinical Chemistry and Coagulation Center, University Hospital Schleswig Holstein, Lübeck/Kiel, Germany.
  • Junker R; Institute for Clinical Chemistry and Coagulation Center, University Hospital Schleswig Holstein, Lübeck/Kiel, Germany.
  • Nowak-Göttl U; Institute for Clinical Chemistry and Coagulation Center, University Hospital Schleswig Holstein, Lübeck/Kiel, Germany.
Acta Haematol ; 144(2): 166-175, 2021.
Article en En | MEDLINE | ID: mdl-32506056
BACKGROUND/AIMS: The newly adapted generic KINDL-A(dult)B(rief) questionnaire showed satisfactory cross-sectional psychometric properties in adults with bleeding disorders or thrombophilia. This investigation aimed to evaluate its cross-sectional and longitudinal construct validity. METHODS: After ethical committee approval and written informed consent, 335 patients (mean age 51.8 ± 16.6 years, 60% women) with either predominant thrombophilia (n = 260) or predominant bleeding disorders (n = 75) participated. At baseline, patients answered the KINDL-AB, the MOS 36-item Short-Form Health Survey (SF-36), and the EQ-5D-3L. A subgroup of 117 patients repeated the questionnaire after a median follow-up of 2.6 years (range: 0.4-3.5). A priori hypotheses were evaluated regarding convergent correlations between KINDL-AB overall well-being and specific subscales, EQ-5D-3L index values (EQ-IV), EQ-5D visual analog scale (EQ-VAS), and SF-36 subscales. RESULTS: Contrary to hypothesis, baseline correlations between the KINDL-AB and EQ-IV/EQ-VAS were all moderate while, as hypothesized, several KINDL-AB subscales and SF-36 subscales correlated strongly. At follow-up, no significant changes in all three instruments occurred. Correlations between instruments over the follow-up were mostly moderate and partially strong. Contrary to hypothesis but consistent with no significant changes in health-related quality of life, convergent correlations between changes in KINDL-AB overall well-being, physical and psychological well-being, and EQ-IV/EQ-VAS were all weak. CONCLUSIONS: While repeated measures of KINDL-AB showed moderate to strong correlations, changes in KINDL-AB overall well-being and subscales correlated more weakly than expected with changes involving two established instruments of generic health status.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Trastornos de la Coagulación Sanguínea / Trombofilia Tipo de estudio: Observational_studies / Prevalence_studies / Qualitative_research / Risk_factors_studies Aspecto: Ethics / Patient_preference Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Haematol Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calidad de Vida / Trastornos de la Coagulación Sanguínea / Trombofilia Tipo de estudio: Observational_studies / Prevalence_studies / Qualitative_research / Risk_factors_studies Aspecto: Ethics / Patient_preference Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Haematol Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza