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LncRNA AK131850 is downregulated in thoracic aortic aneurysm and negatively affects the levels of TGF-ß1 in aortic smooth muscle cells.
Cai, Xiulei; Li, Yongqi; Fu, Shengjie; Wang, Han; Liu, Bing; Tian, Yu; Li, Lei.
Afiliación
  • Cai X; College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.
  • Li Y; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
  • Fu S; Department of Vascular Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
  • Wang H; Department of Vascular Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
  • Liu B; Department of Vascular Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
  • Tian Y; Department of Vascular Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
  • Li L; Department of Vascular Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Arch Physiol Biochem ; 128(5): 1302-1307, 2022 Oct.
Article en En | MEDLINE | ID: mdl-32501722
This study aimed to investigate the role of lncRNA AK131850 in thoracic aortic aneurysm (TAA). We found that AK131850 was downregulated, while TGF-ß1 was upregulated in aortic media specimen of thoracic aortic aneurysm (TAA) patients. In addition, AK131850 and TGF-ß1 inversely correlated. Altered expression levels of AK131850 and TGF-ß1 distinguished TAA patients from healthy controls. In human aortic smooth muscle cells (HAOSMC), AK131850 overexpression led to downregulated, while AK131850 siRNA silencing led to upregulated TGF-ß1. AK131850 overexpression resulted in promoted, while siRNA silencing led to inhibited proliferation of HAOSMC. Therefore, AK131850 is downregulated in thoracic aortic aneurysm and negatively affects the levels of TGF-ß1 in aortic smooth muscle cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aneurisma de la Aorta Torácica / ARN Largo no Codificante Límite: Humans Idioma: En Revista: Arch Physiol Biochem Asunto de la revista: BIOQUIMICA / FISIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aneurisma de la Aorta Torácica / ARN Largo no Codificante Límite: Humans Idioma: En Revista: Arch Physiol Biochem Asunto de la revista: BIOQUIMICA / FISIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido