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Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release.
Bailey, Henry J; Bezerra, Gustavo A; Marcero, Jason R; Padhi, Siladitya; Foster, William R; Rembeza, Elzbieta; Roy, Arijit; Bishop, David F; Desnick, Robert J; Bulusu, Gopalakrishnan; Dailey, Harry A; Yue, Wyatt W.
Afiliación
  • Bailey HJ; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
  • Bezerra GA; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
  • Marcero JR; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.
  • Padhi S; TCS Innovation Labs-Hyderabad (Life Sciences Division), Tata Consultancy Services Ltd, Hyderabad, 500081, India.
  • Foster WR; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
  • Rembeza E; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK.
  • Roy A; TCS Innovation Labs-Hyderabad (Life Sciences Division), Tata Consultancy Services Ltd, Hyderabad, 500081, India.
  • Bishop DF; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Desnick RJ; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
  • Bulusu G; TCS Innovation Labs-Hyderabad (Life Sciences Division), Tata Consultancy Services Ltd, Hyderabad, 500081, India.
  • Dailey HA; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA.
  • Yue WW; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ, UK. wyatt.yue@sgc.ox.ac.uk.
Nat Commun ; 11(1): 2813, 2020 06 04.
Article en En | MEDLINE | ID: mdl-32499479
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación Enzimológica de la Expresión Génica / 5-Aminolevulinato Sintetasa Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación Enzimológica de la Expresión Génica / 5-Aminolevulinato Sintetasa Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Reino Unido