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Obstructive Sleep Apnea and Circulating Biomarkers of Oxidative Stress: A Cross-Sectional Study.
Peres, Bernardo U; Allen, A J Hirsch; Shah, Aditi; Fox, Nurit; Laher, Ismail; Almeida, Fernanda; Jen, Rachel; Ayas, Najib.
Afiliación
  • Peres BU; Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
  • Allen AJH; Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
  • Shah A; Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
  • Fox N; Leon Judah Blackmore Sleep Disorders Program, UBC Hospital, Vancouver, BC V6T 2B5, Canada.
  • Laher I; Canadian Sleep and Circadian Network, Montréal, QC H4J 1C5, Canada.
  • Almeida F; Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
  • Jen R; Department of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 2A1, Canada.
  • Ayas N; Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Antioxidants (Basel) ; 9(6)2020 Jun 02.
Article en En | MEDLINE | ID: mdl-32498324
Oxidative stress (OS) drives cardiometabolic diseases. Intermittent hypoxia consistently increases oxidative stress markers. Obstructive sleep apnea (OSA) patients experience intermittent hypoxia and an increased rate of cardiovascular disease, however, the impact of OSA on OS markers is not clear. The objective was to assess relationships between OSA severity and biomarker levels. Patients with suspected OSA referred for a polysomnogram (PSG) provided fasting blood sample. Plasma levels of 8-isoprostane, 8-hydroxydeoxyguanosine (8-OHdG), and superoxide dismutase (SOD) were measured. The relationship between OSA and OS was assessed both before and after controlling for confounders (age, sex, smoking history, history of cardiovascular disease, ethnicity, diabetes, statin usage, body mass index (BMI)). 402 patients were studied (68% male, mean age ± SD = 50.8 ± 11.8 years, apnea-hypopnea index (AHI) = 22.2 ± 21.6 events/hour, BMI = 31.62 ± 6.49 kg/m2). In a multivariable regression, the AHI significantly predicted 8-isoprostane levels (p = 0.0008) together with age and statin usage; AHI was not a predictor of 8-OHdG or SOD. Female sex (p < 0.0001) and no previous history of cardiovascular disease (p = 0.002) were associated with increased antioxidant capacity. Circulating 8-isoprostane levels may be a promising biomarker of the severity of oxidative stress in OSA patients. Prospective studies are needed to determine whether this biomarker is associated with long-term cardiometabolic complications in OSA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Antioxidants (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Antioxidants (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza