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Somatostatin enhances visual processing and perception by suppressing excitatory inputs to parvalbumin-positive interneurons in V1.
Song, You-Hyang; Hwang, Yang-Sun; Kim, Kwansoo; Lee, Hyoung-Ro; Kim, Jae-Hyun; Maclachlan, Catherine; Dubois, Anaelle; Jung, Min Whan; Petersen, Carl C H; Knott, Graham; Lee, Suk-Ho; Lee, Seung-Hee.
Afiliación
  • Song YH; Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea.
  • Hwang YS; Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea.
  • Kim K; Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea.
  • Lee HR; Department of Physiology, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Kim JH; Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea.
  • Maclachlan C; Biological Electron Microscopy Facility, Centre of Electron Microscopy, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
  • Dubois A; Biological Electron Microscopy Facility, Centre of Electron Microscopy, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
  • Jung MW; Center for Synaptic Brain Dysfunctions, Institute for Basic Science and Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea.
  • Petersen CCH; Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
  • Knott G; Biological Electron Microscopy Facility, Centre of Electron Microscopy, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
  • Lee SH; Department of Physiology, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Lee SH; Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea.
Sci Adv ; 6(17): eaaz0517, 2020 04.
Article en En | MEDLINE | ID: mdl-32494634
Somatostatin (SST) is a neuropeptide expressed in a major subtype of GABAergic interneurons in the cortex. Despite abundant expression of SST and its receptors, their modulatory function in cortical processing remains unclear. Here, we found that SST application in the primary visual cortex (V1) improves visual discrimination in freely moving mice and enhances orientation selectivity of V1 neurons. We also found that SST reduced excitatory synaptic transmission to parvalbumin-positive (PV+) fast-spiking interneurons but not to regular-spiking neurons. Last, using serial block-face scanning electron microscopy (SBEM), we found that axons of SST+ neurons in V1 often contact other axons that exhibit excitatory synapses onto the soma and proximal dendrites of the PV+ neuron. Collectively, our results demonstrate that the neuropeptide SST improves visual perception by enhancing visual gain of V1 neurons via a reduction in excitatory synaptic transmission to PV+ inhibitory neurons.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Sci Adv Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Sci Adv Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos