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Maternal exercise via exerkine apelin enhances brown adipogenesis and prevents metabolic dysfunction in offspring mice.
Son, Jun Seok; Zhao, Liang; Chen, Yanting; Chen, Ke; Chae, Song Ah; de Avila, Jeanene M; Wang, Hongyang; Zhu, Mei-Jun; Jiang, Zhihua; Du, Min.
Afiliación
  • Son JS; Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA.
  • Zhao L; Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA.
  • Chen Y; Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA.
  • Chen K; Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA.
  • Chae SA; Department of Movement Sciences, University of Idaho, Moscow, ID 83844, USA.
  • de Avila JM; Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA.
  • Wang H; Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA.
  • Zhu MJ; School of Food Science, Washington State University, Pullman, WA 99164, USA.
  • Jiang Z; Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA.
  • Du M; Nutrigenomics and Growth Biology Laboratory, Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA.
Sci Adv ; 6(16): eaaz0359, 2020 04.
Article en En | MEDLINE | ID: mdl-32494609
The obesity rate is rapidly increasing, which has been attributed to lack of exercise and excessive energy intake. Here, we found a previously unidentified explanation, due to lack of maternal exercise. In this study, healthy maternal mice were assigned either to a sedentary lifestyle or to exercise daily, and fetal brown adipose tissue (BAT) development and offspring metabolic health were analyzed. Compared to the sedentary group, maternal exercise enhanced DNA demethylation of Prdm16 promoter and BAT development and prevented obesity of offspring when challenged with a high-energy diet. Apelin, an exerkine, was elevated in both maternal and fetal circulations due to exercise, and maternal administration of apelin mimicked the beneficial effects of exercise on fetal BAT development and offspring metabolic health. Together, maternal exercise enhances thermogenesis and the metabolic health of offspring mice, suggesting that the sedentary lifestyle during pregnancy contributes to the obesity epidemic in modern societies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Termogénesis / Adipogénesis Tipo de estudio: Etiology_studies Límite: Animals / Pregnancy Idioma: En Revista: Sci Adv Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Termogénesis / Adipogénesis Tipo de estudio: Etiology_studies Límite: Animals / Pregnancy Idioma: En Revista: Sci Adv Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos