Your browser doesn't support javascript.
loading
Chondral and Osteochondral Femoral Cartilage Lesions Treated with GelrinC: Significant Improvement of Radiological Outcome Over Time and Zonal Variation of the Repair Tissue Based on T2 Mapping at 24 Months.
Schreiner, Markus M; Raudner, Marcus; Szomolanyi, Pavol; Ohel, Kitty; Ben-Zur, Livnat; Juras, Vladimir; Mlynarik, Vladimir; Windhager, Reinhard; Trattnig, Siegfried.
Afiliación
  • Schreiner MM; Department of Orthopedics and Trauma Surgery, Medical University of Vienna, Vienna, Austria.
  • Raudner M; High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, CD Laboratory for Clinical Molecular MR Imaging, Medical University of Vienna, Vienna, Austria.
  • Szomolanyi P; High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, CD Laboratory for Clinical Molecular MR Imaging, Medical University of Vienna, Vienna, Austria.
  • Ohel K; Regentis Biomaterials Ltd., Or Akiva, Israel.
  • Ben-Zur L; Regentis Biomaterials Ltd., Or Akiva, Israel.
  • Juras V; High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, CD Laboratory for Clinical Molecular MR Imaging, Medical University of Vienna, Vienna, Austria.
  • Mlynarik V; High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, CD Laboratory for Clinical Molecular MR Imaging, Medical University of Vienna, Vienna, Austria.
  • Windhager R; Department of Orthopedics and Trauma Surgery, Medical University of Vienna, Vienna, Austria.
  • Trattnig S; High Field MR Center, Department of Biomedical Imaging and Image-Guided Therapy, CD Laboratory for Clinical Molecular MR Imaging, Medical University of Vienna, Vienna, Austria.
Cartilage ; 13(1_suppl): 604S-616S, 2021 12.
Article en En | MEDLINE | ID: mdl-32493044
OBJECTIVE: To prospectively assess the efficacy of GelrinC in the treatment of chondral and osteochondral femoral cartilage lesions using morphological (Magnetic Resonance Observation of Cartilage Repair Tissue [MOCART]) and quantitative (T2-mapping) magnetic resonance imaging (MRI). DESIGN: This study was designed as a prospective single-arm, open label, multicenter study. Morphological magnetic resonance imaging (MRI) for MOCART assessment and T2 mapping was performed 1 week and 6, 12, 18, and 24 months after GelrinC implantation. Evaluation of T2 mapping was based on the assessment of global T2 indices (T2 of the repair tissue [RT] divided by T2 of healthy reference cartilage) and zonal variation. RESULTS: Fifty-six (20 female) patients were prospectively enrolled. The mean MOCART score significantly increased from baseline to the 24-month follow-up with 88.8 (95% CI, 85.8-91.9; P < 0.001) for all lesions combined as well as 86.8 (95% CI, 83.0-90.6) for chondral lesions and 94.1 (95% CI, 68.55-100) for osteochondral lesions. Furthermore, based on T2 mapping, significant zonal variation of the RT was observed at 24 months (P = 0.039), which did not differ significantly from healthy reference cartilage (P = 0.6). CONCLUSION: Increasing MOCART scores were observed throughout the follow-up period, indicative of maturation of the cartilage repair. Significant zonal variation of the RT at 24 months might indicate the transformation into hyaline cartilage-like RT. Slightly differing morphological outcome between chondral and osteochondral lesions, but similar global and zonal T2 indices at 24 months, support the potential of GelrinC as a treatment option for both lesion types.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Cartílago Hialino Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Female / Humans Idioma: En Revista: Cartilage Año: 2021 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Cartílago Hialino Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Female / Humans Idioma: En Revista: Cartilage Año: 2021 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos