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Alcohol Use Disorder Masks the Effects of Childhood Adversity, Lifetime Trauma, and Chronic Stress on Hypothalamic-Pituitary-Adrenal Axis Reactivity.
Zhang, Alice; Price, Julianne L; Leonard, David; North, Carol S; Suris, Alina; Javors, Martin A; Adinoff, Bryon.
Afiliación
  • Zhang A; From the, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Price JL; Department of Psychology, University of Florida, Gainesville, Florida.
  • Leonard D; Department of Psychiatry, University of Florida, Gainesville, Florida.
  • North CS; David Leonard Statistical Consulting, Wichita Falls, Texas.
  • Suris A; From the, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Javors MA; From the, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas.
  • Adinoff B; Mental Health, VA North Texas Health Care System, Dallas, Texas.
Alcohol Clin Exp Res ; 44(6): 1192-1203, 2020 06.
Article en En | MEDLINE | ID: mdl-32491213
BACKGROUND: Individuals with alcohol use disorder (AUD) and those who have experienced traumas or chronic stress exhibit dysregulated hypothalamic-pituitary-adrenal (HPA) axis reactivity. Whether and how trauma and stress histories interact with AUD to affect HPA axis reactivity has not been assessed. METHODS: In the present study, 26 healthy male controls and 70 abstinent men with AUD were administered a pharmacologic probe [ovine corticotropin-releasing hormone (oCRH)] and psychosocial stressor to assess HPA axis reactivity. Plasma adrenocorticotropin hormone (ACTH) and cortisol were assessed every 10-20 minutes. Hierarchical clustering of multiple measures of trauma and stress identified 3 distinct clusters: childhood adversity, lifetime trauma, and chronic stress. General linear model procedures were used to examine main effects of group (AUD/control) and interaction effects of the 3 clusters upon net-integrated ACTH and cortisol response. RESULTS: We found that higher levels of childhood adversity, lifetime trauma, and chronic stress were each associated with blunted oCRH-induced ACTH reactivity in controls, but not in the AUD group. Recent chronic stress within the prior 6 months had the strongest influence upon ACTH reactivity in the control group, and lifetime trauma, the least. CONCLUSIONS: Childhood adversity, lifetime trauma, and chronic stress likely exert persistent, measurable effects upon HPA axis functioning in healthy controls. This association appears to be masked in individuals with AUD, potentially confounding studies examining the effects of stress, adversity, and/or trauma upon the HPA axis in this population during the protracted withdrawal phase of recovery. Future work targeting stress exposure and reactivity should consider the heightened effect of previous alcohol use relative to past adversity and trauma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Hipófiso-Suprarrenal / Estrés Psicológico / Alcoholismo / Trauma Psicológico / Experiencias Adversas de la Infancia / Sistema Hipotálamo-Hipofisario Tipo de estudio: Prognostic_studies Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Alcohol Clin Exp Res Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Hipófiso-Suprarrenal / Estrés Psicológico / Alcoholismo / Trauma Psicológico / Experiencias Adversas de la Infancia / Sistema Hipotálamo-Hipofisario Tipo de estudio: Prognostic_studies Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Alcohol Clin Exp Res Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido