Your browser doesn't support javascript.
loading
Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence.
Toda, Haruka; Diaz-Varela, Miriam; Segui-Barber, Joan; Roobsoong, Wanlapa; Baro, Barbara; Garcia-Silva, Susana; Galiano, Alicia; Gualdrón-López, Melisa; Almeida, Anne C G; Brito, Marcelo A M; de Melo, Gisely Cardoso; Aparici-Herraiz, Iris; Castro-Cavadía, Carlos; Monteiro, Wuelton Marcelo; Borràs, Eva; Sabidó, Eduard; Almeida, Igor C; Chojnacki, Jakub; Martinez-Picado, Javier; Calvo, Maria; Armengol, Pilar; Carmona-Fonseca, Jaime; Yasnot, Maria Fernanda; Lauzurica, Ricardo; Marcilla, Antonio; Peinado, Hector; Galinski, Mary R; Lacerda, Marcus V G; Sattabongkot, Jetsumon; Fernandez-Becerra, Carmen; Del Portillo, Hernando A.
Afiliación
  • Toda H; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, 08036, Spain.
  • Diaz-Varela M; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, 08036, Spain.
  • Segui-Barber J; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, 08036, Spain.
  • Roobsoong W; Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
  • Baro B; Fundaçao de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, 69040-000, Brazil.
  • Garcia-Silva S; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
  • Galiano A; Microenvironment and Metastasis Laboratory, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid, 28029, Spain.
  • Gualdrón-López M; Àrea de Parasitologia, Departament de Farmàcia i Tecnologia Farmacèutica i Parasitologia, Universitat de València, Burjassot, Valencia, 46100, Spain.
  • Almeida ACG; Germans Trias i Pujol Health Science Research Institute (IGTP), Badalona, 08916, Spain.
  • Brito MAM; Fundaçao de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, 69040-000, Brazil.
  • de Melo GC; Universidade do Estado do Amazonas (UEA), Manaus, Amazonas, 69020-070, Brazil.
  • Aparici-Herraiz I; Fundaçao de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, 69040-000, Brazil.
  • Castro-Cavadía C; Universidade do Estado do Amazonas (UEA), Manaus, Amazonas, 69020-070, Brazil.
  • Monteiro WM; Fundaçao de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, 69040-000, Brazil.
  • Borràs E; Universidade do Estado do Amazonas (UEA), Manaus, Amazonas, 69020-070, Brazil.
  • Sabidó E; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, 08036, Spain.
  • Almeida IC; Grupo de Salud y Comunidad Cesar Uribe Piedrahíta, Universidad de Antioquia, Medellín, Colombia.
  • Chojnacki J; Fundaçao de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD), Manaus, Amazonas, 69040-000, Brazil.
  • Martinez-Picado J; Universidade do Estado do Amazonas (UEA), Manaus, Amazonas, 69020-070, Brazil.
  • Calvo M; Proteomics Unit, Centre de Regulació Genòmica (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, 08003, Spain.
  • Armengol P; Universitat Pompeu Fabra (UPF), Barcelona, 08002, Spain.
  • Carmona-Fonseca J; Proteomics Unit, Centre de Regulació Genòmica (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, 08003, Spain.
  • Yasnot MF; Universitat Pompeu Fabra (UPF), Barcelona, 08002, Spain.
  • Lauzurica R; Border Biomedical Research Center, Department of Biological Sciences, College of Science, University of Texas El Paso, El Paso, TX, 79902, USA.
  • Marcilla A; AIDS Research Institute IrsiCaixa, Badalona, 08916, Spain.
  • Peinado H; Germans Trias i Pujol Health Science Research Institute (IGTP), Badalona, 08916, Spain.
  • Galinski MR; AIDS Research Institute IrsiCaixa, Badalona, 08916, Spain.
  • Lacerda MVG; University of Vic-Central University of Catalonia, Vic, 08500, Spain.
  • Sattabongkot J; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, 08010, Spain.
  • Fernandez-Becerra C; Unitat de Microscopia Òptica Avançada, Facultat de Medicina, Centres Científics i Tecnològics, Universitat de Barcelona, Barcelona, 08028, Spain.
  • Del Portillo HA; Germans Trias i Pujol Health Science Research Institute (IGTP), Badalona, 08916, Spain.
Nat Commun ; 11(1): 2761, 2020 06 02.
Article en En | MEDLINE | ID: mdl-32487994
Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) are therefore major components of circulating plasma holding insights into pathological processes. Here, we demonstrate that plasma-derived EVs from Plasmodium vivax patients (PvEVs) are preferentially uptaken by human spleen fibroblasts (hSFs) as compared to the uptake of EVs from healthy individuals. Moreover, this uptake induces specific upregulation of ICAM-1 associated with the translocation of NF-kB to the nucleus. After this uptake, P. vivax-infected reticulocytes obtained from patients show specific adhesion properties to hSFs, reversed by inhibiting NF-kB translocation to the nucleus. Together, these data provide physiological EV-based insights into the mechanisms of human malaria pathology and support the existence of P. vivax-adherent parasite subpopulations in the microvasculature of the human spleen.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasma / Plasmodium vivax / Reticulocitos / Bazo / FN-kappa B / Fibroblastos / Vesículas Extracelulares Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasma / Plasmodium vivax / Reticulocitos / Bazo / FN-kappa B / Fibroblastos / Vesículas Extracelulares Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido