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Cabozantinib Inhibits Photodynamic Therapy-Induced Auto- and Paracrine MET Signaling in Heterotypic Pancreatic Microtumors.
Broekgaarden, Mans; Alkhateeb, Ahmed; Bano, Shazia; Bulin, Anne-Laure; Obaid, Girgis; Rizvi, Imran; Hasan, Tayyaba.
Afiliación
  • Broekgaarden M; Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School/Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114, USA.
  • Alkhateeb A; Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School/Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114, USA.
  • Bano S; Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School/Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114, USA.
  • Bulin AL; Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School/Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114, USA.
  • Obaid G; Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School/Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114, USA.
  • Rizvi I; Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School/Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114, USA.
  • Hasan T; Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School/Massachusetts General Hospital, 40 Blossom Street, Boston, MA 02114, USA.
Cancers (Basel) ; 12(6)2020 May 29.
Article en En | MEDLINE | ID: mdl-32485915
Extensive desmoplasia is a hallmark of pancreatic ductal adenocarcinoma (PDAC), which frequently associates with treatment resistance. Recent findings indicate that a combination of photodynamic therapy and the multi-kinase inhibitor cabozantinib achieved local tumor control and a significant decrease in tumor metastases in preclinical PDAC models, but the underlying therapeutic mechanisms remain unclear. This study elucidates the molecular basis of this multi-agent regimen, focusing on the role of MET signaling. Since MET activation stems from its interaction with hepatocyte growth factor (HGF), which is typically secreted by fibroblasts, we developed heterotypic PDAC microtumor models that recapitulate these interactions. In these models, MET signaling can be constitutively activated through paracrine and autocrine mechanisms. Photodynamic therapy caused significant elevations in HGF secretion by fibroblasts, suggesting it plays a complex role in the modulation of the paracrine HGF-MET signaling cascade in desmoplastic tumors. Blocking MET phosphorylation with adjuvant cabozantinib caused a significant improvement in photodynamic therapy efficacy, most notably by elevating spheroid necrosis at low radiant exposures. These findings highlight that adjuvant photodynamic therapy can augment chemotherapy efficacies, and potentially achieve improved management of desmoplastic PDAC in a more tolerable manner.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Cancers (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Cancers (Basel) Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza