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Synthesis, Characterization and Biological Evaluation of Metal Adamantyl 2-Pyridylhydrazone Complexes.
Shehadi, Ihsan A; Delmani, Fatima-Azzahra; Jaber, Areej M; Hammad, Hana; AlDamen, Murad A; Al-Qawasmeh, Raed A; Khanfar, Monther A.
Afiliación
  • Shehadi IA; Department of Chemistry, Faculty of Sciences, University of Sharjah, Sharjah 27272, UAE.
  • Delmani FA; Department of Biology, Faculty of Science, Jerash University, Jerash 26150, Jordan.
  • Jaber AM; Department of Chemistry, Faculty of Science, The University of Jordan, Amman 11942, Jordan.
  • Hammad H; Department of Biology, Faculty of Science, The University of Jordan, Amman 11942, Jordan.
  • AlDamen MA; Department of Chemistry, Faculty of Science, The University of Jordan, Amman 11942, Jordan.
  • Al-Qawasmeh RA; Department of Chemistry, Faculty of Sciences, University of Sharjah, Sharjah 27272, UAE.
  • Khanfar MA; Department of Chemistry, Faculty of Science, The University of Jordan, Amman 11942, Jordan.
Molecules ; 25(11)2020 May 29.
Article en En | MEDLINE | ID: mdl-32485892
Four new complexes derived from adamantly containing hydrazone (APH) ligand with Cu(II) (1), Co(II) (2), Ni(II) (3) and Zn(II) (4), have been synthesized and characterized using different physicochemical methods. The structure of the ligand APH and its copper complex 1 have been established by single-crystal X-ray diffraction direct methods, which reveal that complex 1 has distorted square-pyramidal geometry. Complexes 1-4 are screened against seven human cancer cell lines namely, breast cancer cell lines (MCF7, T47D, MDA-MB-231), prostate cancer cell lines (PC3, DU145) and the colorectal cancer cell line Coco-2, for their antiproliferative activities. Complex 1 has shown a promising anticancer activity compared to the other ones. The structural and spectroscopic analysis of APH and its complexes are confirmed by DFT calculations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ensayos de Selección de Medicamentos Antitumorales / Técnicas de Química Sintética / Hidrazonas / Antineoplásicos Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Suiza
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ensayos de Selección de Medicamentos Antitumorales / Técnicas de Química Sintética / Hidrazonas / Antineoplásicos Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Suiza